Journal of Flow Chemistry, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 7, 2024
Language: Английский
Journal of Flow Chemistry, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 7, 2024
Language: Английский
JACS Au, Journal Year: 2025, Volume and Issue: 5(2), P. 684 - 692
Published: Feb. 2, 2025
Herein, we report a scalable and mild strategy for the monofluoroalkylation of wide array Giese acceptors via visible-light-mediated photoredox catalysis in continuous flow. The use flow technology significantly enhances productivity scalability, whereas mildness conditions functional group tolerance are ensured by leveraging 4CzIPN, transition-metal-free organic photocatalyst. Structurally diverse secondary tertiary monofluoroalkyl radicals can thus be accessed from readily available α-monofluorocarboxylic acids. Given reaction conditions, this protocol is also amenable to late-stage functionalization biologically relevant molecules such as menthol, amantadine, bepotastine, estrone derivatives, rendering it suitable application drug discovery programs, which introduction fluorinated fragments highly sought after. This method was extended enable reductive multicomponent radical-polar crossover transformation rapidly increase complexity assembled architectures single synthetic operation.
Language: Английский
Citations
3Organic Letters, Journal Year: 2025, Volume and Issue: unknown
Published: March 20, 2025
The bicyclo[1.1.0]butyl scaffold has emerged as a valuable bioisostere in drug discovery programs. Here, we present streamlined approach for the generation of bicyclo[1.1.0]butyllithium and its functionalization with various classes electrophiles one-flow process, eliminating need intermediate isolation. In comparison to traditional batch processes, flow method allows use single organolithium reagent instead two operates at significantly higher temperatures (0 °C versus −78 °C), enhancing both practicality scalability.
Language: Английский
Citations
0Chemical Communications, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Developments in the synthesis and application of strained spiro heterocycles are discussed, given their potential as non-classical rigid three-dimensional bioisosteres drug development.
Language: Английский
Citations
0Organic Letters, Journal Year: 2025, Volume and Issue: unknown
Published: May 21, 2025
The cyclopropene scaffold has emerged as a valuable platform in modern synthesis. Here, we present streamlined flow-based approach for the generation of cyclopropenyllithium and its functionalization with various electrophiles single, continuous flow process. This method eliminates need laborious temperature changes cryogenic conditions, significantly reduces process time from starting material to products. Compared traditional batch processes, our enables use single organolithium reagent operates efficiently at 0 °C, avoiding cool-warm-cool cycles typical methods. not only simplifies workflow but also enhances practicality, scalability, extends accessible chemical space.
Language: Английский
Citations
0Journal of Flow Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: May 26, 2025
Language: Английский
Citations
0Chemical Communications, Journal Year: 2024, Volume and Issue: 60(77), P. 10736 - 10739
Published: Jan. 1, 2024
We have developed a phosphine catalyzed asymmetric [3+2] cyclization of 3-oxetanone derived MBH carbonates with activated methyleneoxindole, to construct oxetane dispirooxindole skeletons. Diastereodivergent synthesis was realized
Language: Английский
Citations
2Synfacts, Journal Year: 2024, Volume and Issue: 20(07), P. 0683 - 0683
Published: June 14, 2024
Key words oxetanes - bioisosteres flash-flow spirocycles late-stage functionalization
Language: Английский
Citations
0Journal of Flow Chemistry, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 18, 2024
Language: Английский
Citations
0Journal of Flow Chemistry, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 7, 2024
Language: Английский
Citations
0