Base-Promoted Annulation of o-(Cyanomethyl)aryl Thioester with Thiophenols to Access 3-Thiolated Isoquinolones

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

An efficient annulation approach to forming 3-thiolated isoquinolones from readily accessible o-(cyanomethyl)aryl thioesters and thiophenols has been established. This metal-free is achieved by taking advantage of solvent-free reactions with no precaution exclude water or air, enabling broad substrate scope good functionality tolerance. Furthermore, the protocol scalable offers facile access valuable without chromatography.

Language: Английский

GreenMedChem-Inspired Light-Air Mediated C(sp3)-H Bond Oxidation: A New tool for Isoquinolone Synthesis

European Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: 288, P. 117414 - 117414

Published: Feb. 19, 2025

Language: Английский

Design, Synthesis, and Antifungal Evaluation of Novel Cuminic Acid Derivatives as Potential Laccase Inhibitors

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 27, 2024

In search of novel natural product-based fungicides, 49 cuminic acid derivatives were designed, synthesized, and screened for their in vitro antifungal effects toward seven phytopathogenic fungi oomycetes. Consequently, several exhibited strong activities

Language: Английский