BINOLates as potent reducing photocatalysts for inert bond activation and reduction of unsaturated systems DOI
Can Liu, Yan Zhang, Rui Shang

et al.

Chem, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский

Electroreduction strategy: a sustainable tool for the generation of aryl radicals DOI
Xiaoqing Xie,

Wei Zhou,

Ruchun Yang

et al.

Organic Chemistry Frontiers, Journal Year: 2024, Volume and Issue: 11(15), P. 4318 - 4342

Published: Jan. 1, 2024

This review primarily focuses on the generation of aryl radicals via an electroreduction strategy, and systematically elaborates synthetic applications, scope, limitations substrates.

Language: Английский

Citations

9
CO2•– Enabled Synthesis of Phenanthridinones, Oxindoles, Isoindolinones, and Spirolactams DOI

Vijay Kumar Simhadri,

Rupam Sur,

Veera Reddy Yatham

et al.

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 28, 2025

We report herein that photoinduced CO2•– enabled reductive intramolecular radical cyclization of a variety aryl iodide derivatives to the corresponding phenanthridinone, oxindole, isoindolinone, and spirolactam in good yields. Preliminary mechanistic studies suggested generation through homolysis cesium formate presence light, further involvement was directly proved by trapping with diphenyl styrene TEMPO.

Language: Английский

Citations

1
Visible-Light-Mediated Radical α-C(sp3)─H gem-Difluoroallylation of Amides with Trifluoromethyl Alkenes via Halogen Atom Transfer and 1,5-Hydrogen Atom Transfer DOI
Dan Liu,

Fang Xiao,

Ben Ebel

et al.

Organic Letters, Journal Year: 2025, Volume and Issue: 27(10), P. 2377 - 2382

Published: March 5, 2025

Direct gem-difluoroallylation at the α-carbonyl position is a challenging process by conventional methods. Herein we report photocatalytic radical α-C(sp3)─H of amides with trifluoromethyl alkenes to access target compounds good yields and functional group tolerance. The mild effective conditions allow gem-difluoroalkene motifs as carbonyl bioisosteres incorporated concisely some complex molecules, including gemfibrozil estrone derivatives, presenting great potential for late-stage functionalization drugs, natural products, bioactive intermediates. Mechanistic investigations suggest pathway combining XAT 1,5-HAT.

Language: Английский

Citations

0
Visible-light-induced radical cascade cyclization of 2-isocyanobiaryls via 1,5-hydrogen atom transfer (1,5-HAT) DOI

Yafei Zhu,

Penghua Zhang,

Xingqin Tian

et al.

Organic Chemistry Frontiers, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

We reported the first example of visible-light-induced radical cascade cyclization 2-isocyanobiaryls via 1,5-HAT, which is characterized by broad substrate scope, excellent functional group compatibility and no requirement any metals base.

Language: Английский

Citations

0
Photoexcited Copper-Catalyzed Difunctionalization of Alkenes for the Synthesis of 2,5-Diamino Acid Derivatives via Uncommon 1,2-Hydrogen Atom Transfer of Amidyl Radicals DOI
Xue Zhang,

Liulin Jiao,

Ting Yuan

et al.

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: May 25, 2025

Compared with 1,5-hydrogen atom transfer (1,5-HAT) processes, 1,2-HAT processes have been reported less frequently. And, the synthesis of 2,5-diamino acid derivatives via a mild photocatalytic approach has not yet. Herein, we report photoexcited copper-catalyzed difunctionalization alkenes for uncommon 1,2-HAT. The potential synthetic merit this reaction is proven through scale-up reaction. Notably, new protocol successfully applied to obtain series derivatives.

Language: Английский

Citations

0
Photoredox-Catalyzed Carbamoyl Radical-Initiated Dearomative Spirocyclization To Access Spiro-Cyclohexadiene Oxindoles DOI
Chunhua Ma, Qing Guo,

Hui Meng

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: 26(40), P. 8503 - 8508

Published: Oct. 1, 2024

The sustainable construction of spirocyclic compounds is important to the scientific community and pharmaceutical industries. Herein, we demonstrate a carbamoyl radical-initiated intramolecular dearomative spirocyclization access spiro-cyclohexadiene oxindoles under visible light irradiation, which constitutes first example accessing I-substituted derivatives that facilitate diversified transformations. Additionally, scalability, late-stage modification drugs, significant antitumor activity products novel synthesis platform for expediting drug development.

Language: Английский

Citations

2
BINOLates as potent reducing photocatalysts for inert bond activation and reduction of unsaturated systems DOI
Can Liu, Yan Zhang, Rui Shang

et al.

Chem, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский

Citations

0