An Organometallic Umpolung Approach for Iron‐Mediated Propargylic C–H Etherification

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 27, 2024

Abstract Propargylic ethers serve as useful intermediates for the synthesis of a variety complex targets. However, propargylic substitution prefunctionalized alkyne starting materials remains dominant method propargyl ethers, while direct etherification simple alkynes via C−H functionalization largely underreported. Herein, we report an organometallic umpolung approach iron‐mediated etherification. A telescopic protocol deprotonation followed by mild oxidative coupling with alcohols enabled use or functionalized expedient excellent functional group compatibility, chemoselectivity and regioselectivity.

Language: Английский

An Organometallic Umpolung Approach for Iron‐Mediated Propargylic C–H Etherification

Angewandte Chemie, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 27, 2024

Abstract Propargylic ethers serve as useful intermediates for the synthesis of a variety complex targets. However, propargylic substitution prefunctionalized alkyne starting materials remains dominant method propargyl ethers, while direct etherification simple alkynes via C−H functionalization largely underreported. Herein, we report an organometallic umpolung approach iron‐mediated etherification. A telescopic protocol deprotonation followed by mild oxidative coupling with alcohols enabled use or functionalized expedient excellent functional group compatibility, chemoselectivity and regioselectivity.

Language: Английский