The Road to Green Efficiency: Exploration of multicomponent reactions from transition metal catalysis to no catalyst conditions DOI
Jie Li, Jiabin Cui,

Hongying Guo

et al.

Reaction Chemistry & Engineering, Journal Year: 2024, Volume and Issue: 10(3), P. 500 - 510

Published: Dec. 20, 2024

Multicomponent reactions (MCRs) have become excellent tools for synthesizing complex and high-value molecules. This minireview highlights recent progresses in MCRs classified by the type of catalysts to offer a better deeper understanding.

Language: Английский

Vinylcyclopropane-Cyclopentene (VCP-CP) Rearrangement Enabled by Pyridine-Assisted Boronyl Radical Catalysis DOI
Ting Li,

Lanfeng Wei,

Zhijun Wang

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: 26(25), P. 5341 - 5346

Published: June 14, 2024

An unprecedented VCP-CP (vinylcyclopropane-cyclopentene) rearrangement approach has been established herein by virtue of the pyridine-boronyl radical catalyzed intramolecular ring expansions. This metal-free pathway harnesses readily available catalysts and unactivated vinylcyclopropane starting materials, providing an array cyclopentene derivatives chemoselectively under relatively mild conditions. Mechanistic studies support idea that boronyl engages in generation allylic/ketyl species, thus inducing opening cyclopropanes following cyclization processes.

Language: Английский

Citations

5
Ruthenium-Catalyzed Remote Trifunctionalization of Non-Activated Alkenes via Cyano Migration and meta-C(sp2)–H Functionalization DOI
Junlei Zhang, Xixi Zhao,

You-Zhi Liao

et al.

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

A novel Ru-catalyzed radical-triggered trifunctionalization of hexenenitriles is presented, employing a strategy remote cyano group migration and meta-C(sp2)-H functionalization. Through migration, the alkenyl moiety undergoes difunctionalization to formation benzylic radical intermediate. This intermediate facilitates para-selective C-H bond addition relative C-Ru within Ru(III) complex, ultimately enabling trifunctionalization. methodology provides an efficient route diverse array nitrile-containing compounds with broad functional compatibility.

Language: Английский

Citations

0
Nickel(II) Chloride Catalyzed and Tetrahydroxydiboron Promoted Denitrative Difluoroalkylation of β‐Nitrovinylarene DOI

Siyi Zhong,

Yingfan Yang,

Xiangwei Ren

et al.

Asian Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: May 26, 2025

Abstract The difluoromethylene (CF 2 ) group is a highly valuable structural unit that significantly contributes to the research and development of novel pharmaceuticals. This work presents an effective synthesis CF ‐containing compounds from β‐nitrostyrene, facilitated by nickel chloride tetrahydroxydiboron. approach simple, efficient, selective, thus providing strategy for utilization β‐nitrostyrene.

Language: Английский

Citations

0
Three-component tandem remote C-H functionalization of naphthalenes by ruthenium catalysis: Modular and concise synthesis of multifunctional naphthalenes DOI Creative Commons

Mao‐Gui Huang,

Yue-Liu-Ting Fu,

Jia‐Wei Li

et al.

Chemical Science, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 12, 2024

A versatile multi-component strategy for synthesizing multi-functional naphthalenes via ruthenium-catalyzed tandem C5–H functionalization from readily available naphthalene, olefin and alkyl bromide compounds is disclosed.

Language: Английский

Citations

1
Rapid and scalable ruthenium catalyzed meta-C–H alkylation enabled by resonant acoustic mixing DOI Creative Commons
Arnab Dey, Rajesh Kancherla, Kuntal Pal

et al.

Communications Chemistry, Journal Year: 2024, Volume and Issue: 7(1)

Published: Dec. 18, 2024

Synthetic chemistry approaches for direct C–H bond alkylation offers a promising alternative to traditional functional-group-centered strategies which often involve multi-step procedures and may suffer from variety of challenges including scalability. Here, we introduce resonant mixing as an efficient method meta-C–H arenes using Ru-catalyst, avoiding the need bulk solvents, external temperature, or light. The described methodology is highly rapid, enabling multigram-scale synthesis meta-alkylation products within short reaction time achieving very high turnover frequency. operates via radical mechanism characterized by its mild conditions, substrate compatibility, exceptional meta-selectivity, all while significantly reducing times. authors acoustic Ru-catalyst mechanism,

Language: Английский

Citations

1
The Road to Green Efficiency: Exploration of multicomponent reactions from transition metal catalysis to no catalyst conditions DOI
Jie Li, Jiabin Cui,

Hongying Guo

et al.

Reaction Chemistry & Engineering, Journal Year: 2024, Volume and Issue: 10(3), P. 500 - 510

Published: Dec. 20, 2024

Multicomponent reactions (MCRs) have become excellent tools for synthesizing complex and high-value molecules. This minireview highlights recent progresses in MCRs classified by the type of catalysts to offer a better deeper understanding.

Language: Английский

Citations

1