Synthesis of (2S,3R,4R)-Dihydroxyisoleucine for Use in Amatoxin Synthesis

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(17), P. 12739 - 12747

Published: Aug. 21, 2024

We report a streamlined synthesis of (2S,3R,4R)-4,5-dihydroxy isoleucine (DHIle), an amino acid found in α-amanitin, which appears to be critical for toxicity. This synthetic route is transition metal-free and enables the production significant quantities DHIle with suitable protection use peptide synthesis. Its incorporation into cytotoxic amatoxin analog reported.

Language: Английский

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Natural Product Reports, Journal Year: 2024, Volume and Issue: 41(6), P. 868 - 872

Published: Jan. 1, 2024

A personal selection of 32 recent papers is presented covering various aspects current developments in bioorganic chemistry and novel natural products, such as penihemeroterpenoid from Penicillium herquei .

Language: Английский