Construction of Phosphonyl and Sulfonyl 3‐Methylene‐Oxindoles via Nucleophilic Vinylic Substitution

ChemistrySelect, Journal Year: 2025, Volume and Issue: 10(11)

Published: March 1, 2025

Abstract 3‐Methylene‐substituted oxindoles play crucial roles as pharmaceutically important reagents well valuable synthons in medicinal and organic synthesis. In this study, a uniform nucleophilic vinylic substitution (S N V) reaction for the construction of phosphonyl sulfonyl substituted 3‐methylene‐oxindole was developed with application ( E )‐3‐(nitromethylene) oxindole powerful precursor. addition, preliminary study revealed that these have potential applications both constructing intriguing molecules serving antibacterial agents.

Language: Английский

Diastereoselective synthesis of 5,5-Difluoroisoxazolidine via [3 + 2] cycloaddition between Nitrones and Difluoroacrylates

Tetrahedron Letters, Journal Year: 2025, Volume and Issue: unknown, P. 155647 - 155647

Published: May 1, 2025

Language: Английский