Rhodium-Catalyzed Asymmetric N2-C5 Allylation of Indazoles with Dienyl Allylic Alcohols
Zhangru Cheng,
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Peng Zhang,
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Ying Shao
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et al.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(27), P. 5646 - 5651
Published: July 2, 2024
The
development
of
site-selective
and
regio-
enantioselective
reactions
substrates
with
multiple
active
sites
is
an
important
topic
remains
a
substantial
challenge
in
synthetic
chemistry.
Here,
we
describe
rhodium-catalyzed
asymmetric
Language: Английский
Chemo- and diastereoselective four-component reactions with Rh carbynoids
Green Synthesis and Catalysis,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 1, 2024
Language: Английский
Rhodium-Catalyzed Enantioselective Ring-Openings of Oxabicyclic Alkenes with Azole Nucleophiles
Matthew T. Zambri,
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Armaan Grewal,
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Mark Lautens
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et al.
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(22), P. 16889 - 16898
Published: Nov. 6, 2024
We
report
enantioselective
ring-openings
of
oxabicyclic
alkenes
with
azole
nucleophiles,
generating
heterocycle-bearing
dihydronaphthalene
products.
Pyrazoles,
triazoles,
tetrazoles,
and
benzo-fused
derivatives
participate
in
the
ring-opening,
level
regioselectivity
depending
on
type
substitution
pattern
heterocyclic
partner.
Electron-withdrawing
substituents
have
a
beneficial
effect,
suppressing
unproductive
complexation
nitrogen
Rh(I)-bis(phosphine)
catalyst.
Language: Английский
Palladium-Catalyzed N-Allylic Alkylation of Pyrazoles and Unactivated Vinylcyclopropanes
Shao-Jie Cheng,
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Xin-Li Zhang,
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Zhongyue Yang
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et al.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 20, 2024
An
efficient
palladium-catalyzed
N-allylic
alkylation
of
pyrazoles
and
unactivated
vinylcyclopropanes
is
demonstrated,
affording
various
N-alkyl
in
≤99%
yield.
This
protocol
displays
high
atom
economy,
a
broad
range
substrates,
excellent
regioselectivity
stereoselectivity.
Late-stage
modification
bioactive
molecules,
scaled-up
reaction,
divergent
derivatization
documented
the
practicability
this
methodology.
The
preliminary
mechanistic
investigation
hinted
that
Pd–H
species
promotes
ring
opening
cyclopropanes.
Language: Английский