Synthesis of γ-Lactams via Palladium-Catalyzed C(sp3)–H Bond Activation of Alkyl Sulfonamides with Substituted Alkenes
Organic Letters,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 20, 2025
A
methodology
for
the
γ-butyrolactam
scaffolds
via
ligand-enabled
C(sp3)–H
bond
functionalization
of
sulfonamides
with
olefins
has
been
demonstrated.
The
protocol
found
to
be
compatible
several
activated
and
unactivated
olefins,
desired
lactams
were
formed
in
excellent
yields.
plausible
mechanism
described
account
lactamization
reaction
as
well
supported
by
mechanistic
investigation
including
a
1H
NMR
study
isolation
palladacycle
intermediate.
Language: Английский
Palladium-Catalyzed Directed Alkenylation of Alkyl Amides with Unactivated Alkenes: Access to γ-Alkenyl γ-Lactams
Organic Letters,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 13, 2025
Pd(II)-catalyzed
cascade
C(sp3)–H
alkenylation
and
cyclization
of
alkyl
amides
with
readily
accessible
unactivated
alkenes
have
been
accomplished.
Alkenylation
subsequent
intramolecular
empowered
the
formation
functionalized
γ-lactams,
which
present
as
an
active
core
several
bioactive
natural
products.
The
use
catalytic
Cu(OAc)2
along
molecular
oxygen
oxidant,
a
2-chloropyridine
ligand,
site
selectivity,
substrate
scope,
gram-scale
synthesis
are
important
practical
features.
Language: Английский