A Photo- and Cobalt-Catalyzed Highly Selective and Divergent Hydrofunctionalization of 1,3-Dienes with Phenols
Chemical Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
An
applicable
cobalt-hydride-mediated
selective,
divergent
hydroetherification
and
sequential
hydroetherification/hydroarylation
of
1,3-dienes
with
simple
phenol
feedstocks
under
a
photoredox
cobalt
catalytic
system
have
been
developed.
A
variety
allyl
aryl
ethers
value-added
chroman
derivatives
can
be
obtained
in
good
to
excellent
yields
stereoselectivity.
This
method
not
only
obviates
the
need
for
extra
hydrosilanes
stoichiometric
oxidants,
thereby
offering
exceedingly
mild
conditions
alkene
hydroetherification,
but
also
represents
first
case
CoH-HAT-catalyzed
double
hydrofunctionalization
alkenes
sole
nucleophile.
The
continuous
selective
bond-forming
expands
applications
cobalt-hydride
MHAT
reaction
provides
novel
approach
design
synthesis
heterocyclic
molecules.
Language: Английский
Recent Advances in Transition-Metal Catalyzed C—H Bond Activation for the Synthesis of C(sp3)-Fluoroalkyl Compounds
Chinese Journal of Organic Chemistry,
Journal Year:
2025,
Volume and Issue:
45(2), P. 516 - 516
Published: Jan. 1, 2025
Language: Английский
Construction of Benzoxazole and Isoquinoline Compounds via Base-Mediated Cyclization of Amino Acid Derivatives
Yilian Song,
No information about this author
Zechao Liu,
No information about this author
Chuangchuang Liu
No information about this author
et al.
Organic Letters,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 19, 2025
Biological
organisms
contain
bioactive
macromolecules
such
as
amino
acids,
which
serve
basic
materials
for
constructing
cells
and
repairing
tissues.
Due
to
the
unique
properties
of
fluorine
atom,
can
alter
structure
proteins
increase
their
lipophilicity,
incorporating
a
atom
into
acids
has
become
research
hotspot.
In
this
study,
ethyl
3-bromo-2-((diphenylmethylene)amino)-3,3-difluoropropanoate
was
synthesized
from
glycine
derivatives.
Under
alkaline
conditions,
compound
reacted
with
2-aminophenol
generate
benzoxazole-containing
acid
derivative.
This
method
is
simple
operate,
without
metal
participation,
performed
under
relatively
eco-friendly
reaction
providing
novel
approach
synthesis
benzoxazole
heterocycles.
Language: Английский
Synthesis of Axially Chiral Monofluoroalkenes via Nickel-Catalyzed Reductive Cross-Coupling of gem-Difluoroalkenes
Organic Letters,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 13, 2024
Enantioenriched
monofluoroalkenes
are
important
structural
motifs
in
life
science
and
functional
materials.
To
date,
only
limited
strategies
were
reported
for
the
synthesis
of
with
stereogenic
carbon
centers;
axially
chiral
counterpart
is
still
highly
desirable.
Herein,
we
report
Ni-catalyzed
defluorinative
cross-electrophile
coupling
Language: Английский
Visible-Light-Induced Photoredox Construction of Trifluoromethylated Quaternary All-Carbon Centers and Tertiary Alcohols via C(sp3)–Si Bond Cleavage
Dachang Bai,
No information about this author
Dandan Ma,
No information about this author
Lingna Chang
No information about this author
et al.
Synthesis,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 10, 2024
Abstract
The
construction
of
trifluoromethylated
quaternary
carbon
centers
and
tertiary
alcohols
is
realized
by
organo-photoredox
catalysis.
process
proceeds
via
visible-light-induced
C(sp3)–Si
bond
cleavage
for
the
generation
α-trifluoromethylated
benzyl
radicals,
which
are
readily
trapped
electron-deficient
alkenes
with
excellent
regioselectivity
all-carbon
centers.
α-difluoromethyl
counterparts
also
suitable
this
radical
conjugate
addition.
Furthermore,
in
situ
oxidation
these
radicals
O2
from
air
affords
high
yields,
extends
Fleming–Tamao
reaction
to
systems.
Language: Английский