ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(45)

Published: Nov. 26, 2024

Abstract The reactivity of ylides possessing additional iodonium functionality is driven by the departure group, which generates highly reactive intermediates. scope these reactions depends on both nature reacting partner and functional groups present at ylidic center. In this study, we investigate phosphonium–iodonium ylides, where carbon atom bonded to a cyclic phenoxaphosphonium moiety various electron‐withdrawing substituents. study examines in with nitriles alkynes, continuing our investigation acyclic triple‐bond‐containing compounds. incorporation phosphorus into structure reveals new bond‐making bond‐breaking patterns leading novel reaction pathway formation enone‐functionalized phosphonates. Phenoxaphosphonium–iodonium furans have been shown antiproliferative activity vitro against several human cancer cell lines.

Language: Английский