Progress in Radical Fluorosulfonyl Reagents DOI
Yi Wang,

Heyin Li

Synthesis, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 11, 2024

Abstract Sulfur(VI) fluoride exchange (SuFEx) chemistry that relies on the unique reactivity–stability balance of high valent organosulfur has emerged as a promising topic for next-generation click reaction. Sulfonyl fluorides are most widely used connective hubs SuFEx reaction with widespread applications in fields chemical biology, drug discovery, and materials science. Compared current methods, direct fluorosulfonylation fluorosulfonyl radicals concise efficient approach production sulfonyl fluorides. The highly active SO2F radical was an unstable inaccessible precursor until it observed decomposition azide, which inspired efforts towards precursors processes. This review presents discusses breakthroughs generation from various precursors, well their application synthesis diverse functionalized 1 Introduction 2 FSO2Cl Radical Precursor 3 Benzimidazolium Fluorosulfonates Precursors 4 Alk-1-ynylsulfonyl Fluorides 5 (Diarylmethylene)sulfamoyl 6 Vinyl Fluorosulfates 7 Conclusion Outlook

Language: Английский

Recent Progress in C–S Bond Formation via Electron Donor-Acceptor Photoactivation DOI
Sichang Wang, Liting Wang, Jin Cui

et al.

Organic & Biomolecular Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

This review summarizes recent progress in EDA complex-promoted C–S bond formation using various sulfur-containing substrates under mild conditions via visible light irradiation.

Language: Английский

Citations

0
Electrochemical Radical Fluorosufonylation of Allyl Bromides DOI

Bingcong Liu,

Hui Liang,

Yanju Lu

et al.

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 20, 2025

A radical fluorosulfonylation of allyl bromides was achieved under electroreductive conditions. This catalyst-free protocol employs mild conditions and enables straightforward access to a new structurally diverse variety previously inaccessible sulfonyl fluorides. We have also illustrated the synthetic value this method by performing scaled-up reactions product derivatization.

Language: Английский

Citations

0
Research Progress in Free Radical Fluorosulfonylation DOI
Jia Zhao,

Qiuyun Gan,

Yaofeng Yuan

et al.

Chinese Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: 45(4), P. 1206 - 1206

Published: Jan. 1, 2025

Language: Английский

Citations

0
Progress in Radical Fluorosulfonyl Reagents DOI
Yi Wang,

Heyin Li

Synthesis, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 11, 2024

Abstract Sulfur(VI) fluoride exchange (SuFEx) chemistry that relies on the unique reactivity–stability balance of high valent organosulfur has emerged as a promising topic for next-generation click reaction. Sulfonyl fluorides are most widely used connective hubs SuFEx reaction with widespread applications in fields chemical biology, drug discovery, and materials science. Compared current methods, direct fluorosulfonylation fluorosulfonyl radicals concise efficient approach production sulfonyl fluorides. The highly active SO2F radical was an unstable inaccessible precursor until it observed decomposition azide, which inspired efforts towards precursors processes. This review presents discusses breakthroughs generation from various precursors, well their application synthesis diverse functionalized 1 Introduction 2 FSO2Cl Radical Precursor 3 Benzimidazolium Fluorosulfonates Precursors 4 Alk-1-ynylsulfonyl Fluorides 5 (Diarylmethylene)sulfamoyl 6 Vinyl Fluorosulfates 7 Conclusion Outlook

Language: Английский

Citations

0