Base-Assisted and Silica Gel-Promoted Indole-Substituted Indene Synthesis

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Herein, we report for the first time a transition-metal-free and mild protocol that requires inexpensive K2CO3 silica gel direct access to polysubstituted indenes from readily obtainable starting precursors. Notably, sequential Michael addition, intramolecular cyclization, gel-promoted nucleophilic substitution reactions afford desired products. A broad range of indoles other aromatic nucleophiles are well-tolerated, affording in moderate good yields. Gratifyingly, indene could be easily converted into synthetically useful 3-indole-substituted indanone indanol. Nonetheless, successful isolation reaction intermediate highlights crucial role methanol this reaction.

Language: Английский

Facile construction of benzofulvene frameworks via a palladium-catalysed three-component reaction

Organic & Biomolecular Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

A palladium-catalysed three-component reaction between 1,3-enynes, 2-formylphenylboronic acids and N -sulfonyl amines has been developed, furnishing a variety of multifunctional benzofulvenes in moderate to good yields E / Z -selectivity.

Language: Английский