Gold Salts as Alternative Catalysts in Promoting Cascade Condensation of 2-Aminobenzaldehydes with Alcohols and Amines DOI

Caterina Momoli,

A. Lamenta,

Marco Chiarini

et al.

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(22), P. 16828 - 16837

Published: Oct. 30, 2024

The distinctive features of gold self-relay catalysts were alternatively utilized in the intriguing cascade condensation 2-aminobenzaldehydes with alcohols and amines. Using NaAuCl4·2H2O as a catalyst, range 13-alkyloxy-7,11b-dihydro-6H,13H-6,12-[1,2]benzenoquinazolino[3,4-a]quinazoline derivatives was produced good to high yields through A3B various alcohols. By carefully choosing reaction conditions, catalysis also proved effective for A2B primary aryl- benzylamines, facilitating synthesis challenging McGeachin bisaminals, including chiral nonracemic derivative 2-(S)-methylbenzylamine. mild conditions this gold-catalyzed approach may lead new advancements field.

Language: Английский

Gold Salts as Alternative Catalysts in Promoting Cascade Condensation of 2-Aminobenzaldehydes with Alcohols and Amines DOI

Caterina Momoli,

A. Lamenta,

Marco Chiarini

et al.

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(22), P. 16828 - 16837

Published: Oct. 30, 2024

The distinctive features of gold self-relay catalysts were alternatively utilized in the intriguing cascade condensation 2-aminobenzaldehydes with alcohols and amines. Using NaAuCl4·2H2O as a catalyst, range 13-alkyloxy-7,11b-dihydro-6H,13H-6,12-[1,2]benzenoquinazolino[3,4-a]quinazoline derivatives was produced good to high yields through A3B various alcohols. By carefully choosing reaction conditions, catalysis also proved effective for A2B primary aryl- benzylamines, facilitating synthesis challenging McGeachin bisaminals, including chiral nonracemic derivative 2-(S)-methylbenzylamine. mild conditions this gold-catalyzed approach may lead new advancements field.

Language: Английский

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