Visible-Light-Induced 4CzIPN-Catalyzed Alkylamination of Alkenes via Cyclobutanone Oxime Esters and Anilines DOI
Jianghong Liu, Zeyu Tian,

Zhen-Ye Wu

et al.

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 22, 2025

We disclosed an organophotoredox-catalyzed three-component oxidative radical-polar crossover strategy for constructing 1,2-alkylamination products. Cycloketone oxime derivatives were used as cyanoalkyl radical precursors and anilines the nucleophiles. This facile protocol shows a good reaction yield broad substrate scope.

Language: Английский

Dual Photoredox and Copper-Catalyzed Asymmetric Remote C(sp3)–H Alkylation of Hydroxamic Acid Derivatives with Glycine Derivatives DOI
Jian Chen,

Pingping Ruan,

Hongying Fan

et al.

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 14, 2025

Dual photoredox and copper-catalyzed remote asymmetric C(sp)3-H alkylation of hydroxamic acid derivatives with glycine via a 1,5-hydrogen transfer (1,5-HAT) process has been realized. The reaction was characterized by redox-neutral mild conditions, good yields, excellent enantioselectivity, broad substrate scope. This protocol provides straightforward efficient strategy to prepare highly valuable enantioenriched noncanonical α-amino acids. Moreover, the potential synthetic value this demonstrated in late-stage dipeptides high diastereomeric ratio.

Language: Английский

Citations

0
Photoredox-catalyzed three-component alkylation of glycine derivatives and peptides via a site-selective 1,5-hydrogen atom transfer cascade DOI

Hongying Fan,

Liulin Jiao,

Ting Yuan

et al.

Organic Chemistry Frontiers, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

We report a visible-light-mediated three-component reaction via 1,5-HAT combined with site-selective remote C(sp 3 )–H cross-coupling reactions of alkenes alkyl radicals for the α-C(sp alkylation glycine derivatives and peptides.

Language: Английский

Citations

0
Visible-light-induced radical cascade cyclization of 2-isocyanobiaryls via 1,5-hydrogen atom transfer (1,5-HAT) DOI

Yafei Zhu,

Penghua Zhang,

Xingqin Tian

et al.

Organic Chemistry Frontiers, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

We reported the first example of visible-light-induced radical cascade cyclization 2-isocyanobiaryls via 1,5-HAT, which is characterized by broad substrate scope, excellent functional group compatibility and no requirement any metals base.

Language: Английский

Citations

0
Visible-Light-Induced 4CzIPN-Catalyzed Alkylamination of Alkenes via Cyclobutanone Oxime Esters and Anilines DOI
Jianghong Liu, Zeyu Tian,

Zhen-Ye Wu

et al.

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 22, 2025

We disclosed an organophotoredox-catalyzed three-component oxidative radical-polar crossover strategy for constructing 1,2-alkylamination products. Cycloketone oxime derivatives were used as cyanoalkyl radical precursors and anilines the nucleophiles. This facile protocol shows a good reaction yield broad substrate scope.

Language: Английский

Citations

0