¹³C‐Labeling as a Method in Organic Synthesis, Catalysis and Biochemical Applications

Chemistry - Methods, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 11, 2024

Abstract The incorporation of a labeled 13 C atom provides plethora opportunities in organic synthesis and catalysis. Structure complicated compounds can be successfully confirmed using the precise location carbon atom; reaction mechanism supported by presence or absence label products; metabolic pathways biological found out depending on concentration analyzed significantly lower for recording successful interpretation NMR spectra, etc . This review aims to provide researcher with common promising strategies so that select an appropriate route save valuable material. All labeling approaches were considered based starting source. Ideological aim is demonstrate find improvements his own topic compounds. Utilization catalysis studying mechanisms also capabilities compounds, which may useful specific tasks applications. potential bioactive compound metabolite analysis was demonstrated selected examples.

Language: Английский

Ru-Catalyzed Switchable Reactions of Acrylic Acids with Glyoxylate: Access to Functionalized γ-Butenolides

Organic Letters, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 8, 2024

We herein report a switchable coupling of acrylic acids with ethyl glyoxylate under ruthenium catalysis enabling the synthesis diverse functionalized γ-butenolides. The carboxyl-directed vinylic C–H cleavage and dual nucleophilic addition to aldehyde are achieved deliver hydroxymethylated butanolides mild oxidant-free conditions. Alternatively, controlled unprecedented tandem cyclization/oxidative homocoupling reaction is realized by using silver salt as oxidant generate range dimeric butenolides bearing vicinal all-carbon quaternary centers.

Language: Английский