Calcium(II)‐Catalyzed Synthesis of Sulfoximinocyclopentenones DOI Creative Commons
Vincent Gandon, Aurélien Alix, Nicolas George

et al.

Advanced Synthesis & Catalysis, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 29, 2024

Abstract A series of 4‐sulfoximinocyclopent‐2‐en‐1‐ones was prepared in 35 to 99% yield through a calcium(II)‐catalyzed aza‐Piancatelli reaction, including enantioenriched form. Depending on their substitution pattern, diverse diastereoselective chemical transformations can be applied these scaffolds, allowing access cyclopentane derivatives. This study opens synthetic routes cyclopentane‐based scaffolds and also paves the way for exploration associated space drug discovery.

Language: Английский

Multicomponent Modular Synthesis of Chiral Bicyclic Bridged Compounds via an Alkenylfuran-Based Acylation/Rearrangement/Cyclization Sequence DOI

Yu Tian,

H. Tao,

Kexin Yang

et al.

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 26, 2025

The catalytic asymmetric multicomponent acylation/rearrangement/cyclization of alkenylfurans with acyl oxime esters/arylamines or esters/arylamines/hydroxylamine has been developed. This method employs synergistic photoredox/Brønsted acid catalysis, enabling the efficient and versatile synthesis multifunctionalized [3.2.1] [4.2.1] bicyclic bridged compounds in high yields excellent diastereo- enantioselectivities.

Language: Английский

Citations

0
Enantioselective Synthesis of N-Substituted Indoles with α,β-Stereocenters via Sequential Aza-Piancatelli/Cyclization Reactions DOI

Kaijun Xie,

Xukun Nie,

Pengfei Zhou

et al.

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: April 29, 2025

A sequence of catalytic asymmetric aza-Piancatelli rearrangement and Pd-catalyzed cyclization has been developed to construct chiral N-substituted indoles featuring α,β-consecutive stereocenters. This indole framework, bearing α,β-chiral centers, is a prevalent structural motif in natural products biologically active molecules, yet enantioselective methods for its preparation remain scarce. protocol offers efficient access diverse array derivatives with stereocenters, achieving high yields excellent enantioselectivities.

Language: Английский

Citations

0
Calcium(II)‐Catalyzed Synthesis of Sulfoximinocyclopentenones DOI Creative Commons
Vincent Gandon, Aurélien Alix, Nicolas George

et al.

Advanced Synthesis & Catalysis, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 29, 2024

Abstract A series of 4‐sulfoximinocyclopent‐2‐en‐1‐ones was prepared in 35 to 99% yield through a calcium(II)‐catalyzed aza‐Piancatelli reaction, including enantioenriched form. Depending on their substitution pattern, diverse diastereoselective chemical transformations can be applied these scaffolds, allowing access cyclopentane derivatives. This study opens synthetic routes cyclopentane‐based scaffolds and also paves the way for exploration associated space drug discovery.

Language: Английский

Citations

1