Copper-Catalyzed Diastereoselective Addition of a [1,1,1]Propellane Dimer to N-tert-Butanesulfinyl Aldimines
Yihui Li,
No information about this author
Yuan Han,
No information about this author
Jia-Xuan Luo
No information about this author
et al.
Organic Letters,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 21, 2025
[1,1,1]Propellane
is
typically
used
as
a
building
block
for
the
construction
of
bicyclo[1,1,1]pentanes
and
cyclobutanes.
In
this
work,
diverse
chiral
bi(methylenecyclobutylidene)
complexes
were
synthesized
by
diastereoselective
addition
[1,1,1]propellane
dimer
to
N-tert-butanesulfinyl
aldimines
in
presence
copper
bipyridine.
Density
functional
theory
calculations
revealed
that
both
step
regeneration
catalyst
contributed
generation
favored
(Ss,S,S)-diastereomer.
Language: Английский
Photocatalytic Difunctionalization of [1.1.1]Propellane
The Chemical Record,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 27, 2025
The
hunt
for
new
molecular
structures
to
improve
the
efficacy
of
biologically
active
molecules
is
at
forefront
pharmaceutical
chemistry.
So
synthetic
chemists
have
always
been
busy
in
last
few
decades
synthesizing
and
testing
frameworks
which
would
work
as
more
efficient
bioisosteres
present
bioactive
functional
groups.
In
this
area,
bicyclo[1.1.1]pentane
(BCP)
framework
has
identified
a
promising
candidate.
It
being
utilized
bioisostere
aryl,
tert-butyl,
alkynes,
etc.
Now
major
precursor
various
BCP
derivatives
[1.1.1]propellane
functionalization
drawn
widespread
attention
organic
chemist
community.
Over
past
two
decades,
use
visible
light
synthesis
rapidly
gained
popularity,
it
represents
one
most
approaches
aligned
with
principles
green
sustainable
chemistry,
several
interesting
papers
covering
photocatalytic
difunctionalization
also
published
decade.
This
particular
field
really
attracted
That
why
we
decided
compile
review
article
articles
related
under
conditions.
Here
review,
categorized
discussed
three
categories,
namely
i)
without
using
any
catalyst,
ii)
organocatalysts,
iii)
metal
catalysts
deeper
understanding
key
aspects
these
transformations.
Language: Английский
Site-selective Alkylation of Electron-deficient Aromatic Cycles: Visible-light Photoredox Catalyzed Radical Di-functionalization of [1.1.1]Propellane
Chengjun Chen,
No information about this author
Xiaoyu Shen,
No information about this author
Shengkun Guo
No information about this author
et al.
Chemical Communications,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
A
visible-light
photoredox-catalyzed
three-component
radical
coupling
of
[1.1.1]propellane
with
electron-deficient
aromatic
cycles
and
Katritzky
salts
to
access
alkyl
arylated
bicyclo[1.1.1]pentanes
was
established.
Language: Английский
Visible-light Mediated Oxidative Diels-Alder Reaction of Hydroxylamines and 1,3-Dienes
Meijun Zhu,
No information about this author
Lanqin Liu,
No information about this author
Yunfei Zhi
No information about this author
et al.
Tetrahedron,
Journal Year:
2025,
Volume and Issue:
unknown, P. 134752 - 134752
Published: May 1, 2025
Language: Английский
Visible-Light-Mediated Perfluoroalkylation/Thioetherification of [1.1.1]Propellane under Photocatalyst-Free Conditions
Jiabin Shen,
No information about this author
Liangfeng Yang,
No information about this author
Ge Kai
No information about this author
et al.
Organic Letters,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 29, 2025
Perfluoroalkyl-functionalized
bicyclo[1.1.1]pentane
(BCP)
derivatives
have
garnered
significant
attention
in
pharmaceuticals
due
to
their
special
physicochemical
property;
however,
establishing
convenient
synthetic
protocols
for
these
fluorinated
molecular
frameworks
continues
present
substantial
methodological
challenges.
Herein,
we
report
a
photocatalyst
and
additive-free
perfluoroalkylation/thioetherification
of
[1.1.1]
propellane
with
disulfide
ether
perfluoroalkyl
iodines.
Such
photochemistry
methodology
utilizing
an
electron
donor-acceptor
(EDA)
complex
offers
green
novel
way
obtain
various
BCP
containing
thioether
groups
good
functional
group
tolerance.
Language: Английский
Visible-light Photoredox-Catalyzed Three-Component Radical Alkyl-Acylation of [1.1.1]Propellane
Lanqin Liu,
No information about this author
Shengkun Guo,
No information about this author
Chengjun Chen
No information about this author
et al.
Organic & Biomolecular Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
A
three-component
radical
alkyl-acylation
of
[1.1.1]propellane
to
access
a
diverse
array
1,3-disubstituted
BCP
ketone
derivatives.
Language: Английский