N2-Alkylation of 1,2,3-Triazoles with Ethers under Thermodynamical Control
Organic Letters,
Journal Year:
2025,
Volume and Issue:
27(6), P. 1428 - 1433
Published: Jan. 31, 2025
Herein,
a
relay
strategy
incorporating
oxidative
cross
dehydrogenative
coupling
(CDC)
and
N1-
to
N2-isomerization
is
disclosed
for
the
formal
N2-selective
alkylation
of
triazoles
with
ethers
under
thermodynamic
control
conditions.
By
taking
advantage
different
thermodynamical
stabilities
N2-alkylated
(3.65
kcal/mol),
initially
formed
N1-isomers
can
be
in
situ
converted
into
their
more
stable
N2-isomers
when
reaching
equilibrium.
PhI(OAc)2
has
been
discovered
function
as
both
an
oxidant
CDC
process
efficient
mediator
isomerization
step.
Language: Английский
Iodine(III)-Containing Reagents in Photo-Assisted and Photo-Catalyzed Organic Synthesis
Molecules,
Journal Year:
2025,
Volume and Issue:
30(4), P. 784 - 784
Published: Feb. 8, 2025
Iodine(III)
reagents
have
become
a
highly
relevant
tool
in
organic
synthesis
due
to
their
great
versatility
as
strong
but
green
oxidants.
Several
transformations
involving
cyclizations
well
functionalization
of
different
cores
been
broadly
described
and
reviewed.
Herein,
the
participation
these
photochemical
exclusively
by
direct
irradition
or
photoredox
cycles
using
some
transition
metals,
will
be
briefly
plausible
further
that
potentially
can
developed.
Language: Английский