Palladium‐Catalyzed Carbonylative Sonogashira Transformations: Advancements and Insights

The Chemical Record, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

Abstract Palladium‐catalyzed carbonylative reactions, used as a tool for the insertion of carbonyl group into organic moieties, is synthetically useful transformation. Carbonylative Sonogashira coupling convenient approach synthesis α,β‐acetylenic ketones which are important class molecules in pharmaceutical and industrial fields. Development greener approaches environmentally benign catalytic systems put forward enormous opportunities this field moreover, these researches indicate formation heterocycles via carbonylation strategy, major highlight. Herein, we discuss progress achieved palladium‐catalyzed from 2013 to 2024 its future prospects.

Language: Английский

Palladium-catalyzed Narasaka–Heck carbonylation for the construction of functionalized ynones

Chemical Communications, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Pd-catalyzed Narasaka–Heck carbonylation efficiently synthesizes functionalized alkynones (70% yield) under mild conditions. This strategy offers a multifunctional platform for bioactive molecule construction in medicinal chemistry.

Language: Английский

Nickel-Catalyzed Gas-Free Reductive Carbonylation of Aryl Thianthrenium Salts to Access Aryl Amides and Aryl Thioesters

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

A nickel-catalyzed site-selective reductive carbonylation of arenes via aryl thianthrenium salts is described. Using Mo(CO)6 as a convenient solid CO source and reductant employing nitroarenes sulfonyl chlorides readily available nitrogen sulfur sources, range amides thioesters were successfully synthesized in moderate to good yields. The utility this transformation demonstrated through the synthesis antimicrobial agents late-stage functionalization biorelevant molecules.

Language: Английский