Copper-PMHS System-Enabled Reductive Cyclization of o-Aminobenzamides with CO2 as a Single-Carbon Synthon DOI
Jiang Nan, Lu Zhang,

Rui Cao

et al.

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 18, 2025

Chemical utilization of carbon dioxide (CO2) has emerged as a sustainable access for synthesizing high-value chemicals. Continuously designing the more practical reaction systems is large importance. Herein, an unprecedented and powerful copper-PMHS reductive system o-aminobenzamides with CO2 disclosed. Synthetically, diverse range quinazolinones (>70 examples) are rapidly assembled excellent functional group tolerance in good yields. Moreover, building other types heterocycles such benzothiazoles benzimidazoles also allowable. Mechanistically, differing from reported carbonylation cases, this finding represents scarce example single-carbon atom synthon PMHS system.

Language: Английский

Photoredox-Mediated Radical Addition/Cyclization To Construct Benzannulated 6,5-Spiroketal Glycosides DOI
Chen Li, Shouyun Yu

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 30, 2025

We herein present a green and mild photoredox strategy for constructing framework of benzannulated 6,5-spiroketal glycosides. This method employs various O-arylacetylene glycosides aryl ketone acids as the starting materials, facilitating rapid straightforward synthesis with up to 92% yields under catalytic conditions. efficient approach has potential significantly enhance molecular library carbohydrate-based pharmaceuticals.

Language: Английский

Citations

0
Copper-PMHS System-Enabled Reductive Cyclization of o-Aminobenzamides with CO2 as a Single-Carbon Synthon DOI
Jiang Nan, Lu Zhang,

Rui Cao

et al.

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 18, 2025

Chemical utilization of carbon dioxide (CO2) has emerged as a sustainable access for synthesizing high-value chemicals. Continuously designing the more practical reaction systems is large importance. Herein, an unprecedented and powerful copper-PMHS reductive system o-aminobenzamides with CO2 disclosed. Synthetically, diverse range quinazolinones (>70 examples) are rapidly assembled excellent functional group tolerance in good yields. Moreover, building other types heterocycles such benzothiazoles benzimidazoles also allowable. Mechanistically, differing from reported carbonylation cases, this finding represents scarce example single-carbon atom synthon PMHS system.

Language: Английский

Citations

0