C3-Heteroarylation of Indoles via Cu(II)-Catalyzed Aminocupration and Subsequent Nucleophilic Addition of o-Alkynylanilines DOI
Amitava Rakshit,

Kyeongwon Moon,

Pargat Singh

et al.

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 23, 2025

Transition-metal-catalyzed aminometalation of o-alkynylanilines is a promising pathway for the synthesis C3-functionalized indoles. Herein, we describe Cu(II)-catalyzed site-selective C3-heteroarylation indoles from and quinoline N-oxides. A plausible reaction mechanism involving aminocupration followed by nucleophilic addition Cu(II)-indolyl complexes to N-oxides was proposed. Post-transformations generated C3-heteroarylated demonstrated broad applicability developed method.

Language: Английский

C3-Heteroarylation of Indoles via Cu(II)-Catalyzed Aminocupration and Subsequent Nucleophilic Addition of o-Alkynylanilines DOI
Amitava Rakshit,

Kyeongwon Moon,

Pargat Singh

et al.

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 23, 2025

Transition-metal-catalyzed aminometalation of o-alkynylanilines is a promising pathway for the synthesis C3-functionalized indoles. Herein, we describe Cu(II)-catalyzed site-selective C3-heteroarylation indoles from and quinoline N-oxides. A plausible reaction mechanism involving aminocupration followed by nucleophilic addition Cu(II)-indolyl complexes to N-oxides was proposed. Post-transformations generated C3-heteroarylated demonstrated broad applicability developed method.

Language: Английский

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