Synthesis of Masked 2-Pyridones from 1,3-Enynyl Esters via Tandem Gold-Catalyzed Cycloisomerization and Oxidative Nitrogen Insertion DOI
Tianyu Lin,

Dandan Shang,

Rui Hu

et al.

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: March 18, 2025

An efficient synthetic method to regioselectively assemble masked 2-pyridones that relies on sequential gold-catalyzed cycloisomerization and phenyliodonium diacetate (PIDA)-mediated oxidative nitrogen insertion from 1,3-enynyl esters in a one-pot, two-step manner is described. The utility of the cascade protocol was further demonstrated by 2 mmol scale synthesis one example its elaboration other potentially useful building blocks as well late-stage modification diverse array structurally complex bioactive molecules.

Language: Английский

Synthesis of Masked 2-Pyridones from 1,3-Enynyl Esters via Tandem Gold-Catalyzed Cycloisomerization and Oxidative Nitrogen Insertion DOI
Tianyu Lin,

Dandan Shang,

Rui Hu

et al.

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: March 18, 2025

An efficient synthetic method to regioselectively assemble masked 2-pyridones that relies on sequential gold-catalyzed cycloisomerization and phenyliodonium diacetate (PIDA)-mediated oxidative nitrogen insertion from 1,3-enynyl esters in a one-pot, two-step manner is described. The utility of the cascade protocol was further demonstrated by 2 mmol scale synthesis one example its elaboration other potentially useful building blocks as well late-stage modification diverse array structurally complex bioactive molecules.

Language: Английский

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