Natural Product Reports, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
A personal selection of 32 recent papers is presented covering various aspects current developments in bioorganic chemistry and novel natural products such as melichuniione from Melicope chunii.
Language: Английский
Journal of Natural Products, Journal Year: 2025, Volume and Issue: unknown
Published: April 18, 2025
Genome mining and heterologous reconstitution of biosynthetic genes in Aspergillus oryzae enabled elucidation the hitherto elusive route that produces allantofuranone (1), a bioactive natural product originally isolated from Allantophomopsis lycopodina. The core non-ribosomal peptide synthetase (NRPS)-like enzyme AlfA alf BGC polyporic acid (2) phenylpyruvic acid. In subsequent reactions, compound 2 is reductively dehydrated by bifunctional AlfC methylated AlfD to produce terferol (6). final step, quinol moiety 6 oxidatively cleaved contracted aromatic ring cleavage dioxygenase AlfB. Using combinatorial biosynthesis, we were able manipulate yield hydroxylated pathway congeners, most notably new products deoxyascocorynin (10), hydroxyterferol (11), hydroxyallantofuranone (12).
Language: Английский
Citations
0
Natural Product Reports, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
A personal selection of 32 recent papers is presented covering various aspects current developments in bioorganic chemistry and novel natural products such as melichuniione from Melicope chunii.
Language: Английский
Citations
0