Rhodium-Catalyzed C(sp2)–H Activation and [3+3] Annulation: Accessing Pyrano[3,2-c]chromene-2,5-diones as TASK-3 Activators DOI
Xueqing Liu, Shuaikang Zheng, Qingjie Ge

et al.

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 21, 2025

Herein, an efficient Rh-catalyzed C-H activation/annulation between α,β-unsaturated amides and coumarin-derived iodonium ylides has been developed, affording novel pyrano[3,2-c]chromene-2,5-diones analogues in high yields. Most products could be easily isolated by precipitation ethanol, followed simple filtration. Additionally, this protocol demonstrated the benefits of environmentally friendly conditions, air compatibility, good functional group scale-up synthesis with low catalyst loading, a recyclable Rh catalyst. Importantly, compounds 3m 3w moderate agonist activity on TASK-3 channel, I/I0 values 1.7650 ± 0.1058 1.400 0.0589, respectively.

Language: Английский

Rhodium-Catalyzed C(sp2)–H Activation and [3+3] Annulation: Accessing Pyrano[3,2-c]chromene-2,5-diones as TASK-3 Activators DOI
Xueqing Liu, Shuaikang Zheng, Qingjie Ge

et al.

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 21, 2025

Herein, an efficient Rh-catalyzed C-H activation/annulation between α,β-unsaturated amides and coumarin-derived iodonium ylides has been developed, affording novel pyrano[3,2-c]chromene-2,5-diones analogues in high yields. Most products could be easily isolated by precipitation ethanol, followed simple filtration. Additionally, this protocol demonstrated the benefits of environmentally friendly conditions, air compatibility, good functional group scale-up synthesis with low catalyst loading, a recyclable Rh catalyst. Importantly, compounds 3m 3w moderate agonist activity on TASK-3 channel, I/I0 values 1.7650 ± 0.1058 1.400 0.0589, respectively.

Language: Английский

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