cis-Diphosphine Ethene Ligand-Ni Complex Catalyzed C-P Cross-Coupling of Aryl Chlorides DOI
Yumeng Wu, Zhe Tang,

Xiaoli Li

et al.

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: June 2, 2025

Nickel complexes supported by cis-diphosphine ethene ligands were synthesized and employed in the C-P coupling reaction of aryl chlorides. The rigid five-membered-ring structure formed bisphosphine with olefinic backbones nickel may be crucial for facilitating reductive elimination step catalytic cycle. steric hindrance electronic properties these have also been shown to a significant effect on rate extent reaction. A series chlorides can smoothly converted corresponding trisubstituted phosphine oxides disubstituted oxides, as well dialkyl phosphites, under mild conditions. system showed good compatibility heterocyclic structures. In addition, this air-stable easy-to-handle complex has demonstrated application potential synthesis pharmaceutical molecules.

Language: Английский

Room-Temperature Copper Cross-Coupling Reactions of Anilines with Aryl Bromides DOI
Jonas Düker, Nele Petersen, Noah Richter

et al.

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: May 28, 2025

We present a novel copper-catalyzed method for aniline cross-couplings promoted by 6-hydroxy picolinhydrazide ligand. The achieves room-temperature reactivity with aryl bromides, enabled methanol/ethanol solvent mixture and mild, functional group-compatible base, catalyst loadings as low 0.5 mol %. use of industrially preferred solvents well the high catalytic activity, offers significant advancement in practicality scalability industrial processes. Furthermore, approach extends to cross-coupling chlorides under elevated temperatures demonstrates compatibility additional nucleophile classes.

Language: Английский

Citations

0
cis-Diphosphine Ethene Ligand-Ni Complex Catalyzed C-P Cross-Coupling of Aryl Chlorides DOI
Yumeng Wu, Zhe Tang,

Xiaoli Li

et al.

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: June 2, 2025

Nickel complexes supported by cis-diphosphine ethene ligands were synthesized and employed in the C-P coupling reaction of aryl chlorides. The rigid five-membered-ring structure formed bisphosphine with olefinic backbones nickel may be crucial for facilitating reductive elimination step catalytic cycle. steric hindrance electronic properties these have also been shown to a significant effect on rate extent reaction. A series chlorides can smoothly converted corresponding trisubstituted phosphine oxides disubstituted oxides, as well dialkyl phosphites, under mild conditions. system showed good compatibility heterocyclic structures. In addition, this air-stable easy-to-handle complex has demonstrated application potential synthesis pharmaceutical molecules.

Language: Английский

Citations

0