Total Syntheses of Uvarindoles A and B, (±)-Pseudophrynaminol, and (±)-Pseudophrynamines 272A and 270 via Dearomative Indole Alkylation DOI

Raju Chouhan,

Sajal Kumar Das

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 31, 2025

Herein, we report the first total synthesis of alkaloid uvarindole B with an overall yield 49% over five steps via double C3-alkylation 5-bromoindole, Plancher rearrangement, and Negishi coupling as key steps. We also disclose short syntheses A, pseudophrynaminol, pseudophrynamines 272A 270 dearomative indole alkylation.

Language: Английский

Total Syntheses of Uvarindoles A and B, (±)-Pseudophrynaminol, and (±)-Pseudophrynamines 272A and 270 via Dearomative Indole Alkylation DOI

Raju Chouhan,

Sajal Kumar Das

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 31, 2025

Herein, we report the first total synthesis of alkaloid uvarindole B with an overall yield 49% over five steps via double C3-alkylation 5-bromoindole, Plancher rearrangement, and Negishi coupling as key steps. We also disclose short syntheses A, pseudophrynaminol, pseudophrynamines 272A 270 dearomative indole alkylation.

Language: Английский

Citations

0