Catalytic dynamic kinetic reductive addition of simple aldehydes and aldimines with heterobiaryl triflates: harnessing both central and axial chirality DOI
Ni Hui, AnYao Liu, Xiaoying Fu

et al.

Organic & Biomolecular Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

A nickel-catalyzed intramolecular dynamic kinetic resolution (DKR) strategy has been developed for the enantioselective synthesis of axially chiral heterobiaryls from racemic azabiaryl triflates. Using a reductive addition mechanism, this method controls both axial and central chirality, offering broad substrate scope, excellent enantioselectivity, atroposelectivity. The resulting were effectively employed as organocatalysts ligands in asymmetric transformations, highlighting their synthetic utility. Mechanistic studies indicate synergy between nickel-mediated stereochemical inversion, addressing challenges concurrent control.

Language: Английский

Catalytic dynamic kinetic reductive addition of simple aldehydes and aldimines with heterobiaryl triflates: harnessing both central and axial chirality DOI
Ni Hui, AnYao Liu, Xiaoying Fu

et al.

Organic & Biomolecular Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

A nickel-catalyzed intramolecular dynamic kinetic resolution (DKR) strategy has been developed for the enantioselective synthesis of axially chiral heterobiaryls from racemic azabiaryl triflates. Using a reductive addition mechanism, this method controls both axial and central chirality, offering broad substrate scope, excellent enantioselectivity, atroposelectivity. The resulting were effectively employed as organocatalysts ligands in asymmetric transformations, highlighting their synthetic utility. Mechanistic studies indicate synergy between nickel-mediated stereochemical inversion, addressing challenges concurrent control.

Language: Английский

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