Comparison of the Reactivities and Selectivities of Group 9 [Cp*M^III] Catalysts in C−H Functionalization Reactions

Chemistry - An Asian Journal, Journal Year: 2018, Volume and Issue: 13(9), P. 1089 - 1102

Published: Feb. 26, 2018

Abstract Pentamethylcyclopentadienyl (Cp*)‐based Group 9 metal (Co, Rh, or Ir) catalysts have emerged as powerful tools for C−H functionalization reactions. Whilst a diverse range of organic transformations been developed by using [Cp*M III ] catalysts, they often exhibited orthogonal reactivities and varied selectivities that depended on the choice central atom. An understanding physicochemical properties metals, well their reaction mechanisms, has led to significant expansion synthetic scope This Focus Review summarizes discusses comparative catalytic with an emphasis metal‐dependent pathway‐switching considering mechanistic rationale.

Language: Английский

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Rh(III)-Catalyzed C–H Functionalization of Indolines with Readily Accessible Amidating Reagent: Synthesis and Anticancer Evaluation

The Journal of Organic Chemistry, Journal Year: 2016, Volume and Issue: 81(20), P. 9878 - 9885

Published: Sept. 28, 2016

The rhodium(III)-catalyzed direct C-H functionalization of various indolines with 1,4,2-dioxazol-5-ones as new amidating agents is described. This transformation provides efficient preparation C7-amidated known to display potent anticancer activity. synthetic compounds were evaluated for in vitro activity against human prostate adenocarcinoma cells (LNCaP), endometrial (Ishikawa), and ovarian carcinoma (SKOV3). Compound 4f was found be highly cytotoxic, competitive that agent doxorubicin.

Language: Английский

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Transition Metal Promoted Cascade Heterocycle Synthesis through C−H Functionalization

Chemistry - A European Journal, Journal Year: 2020, Volume and Issue: 26(44), P. 9749 - 9783

Published: June 18, 2020

Sequential, domino and tandem reactions could be defined as a sequence of synthetic transformations that occur one after the other, in same reaction flask. This Review highlights recent advances at overlap two worlds: transition-metal mediated C-H activation trigger cascade reaction, for heterocycles synthesis. To shed some light on this intricate "middle-earth", focus was put mechanism rather than type metal or chronological order reaction. The aim is to separate, then highlight, true initiated by activation, compared other examples functionalization heterocycle syntheses.

Language: Английский

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Chemical Insights Into the Synthetic Chemistry of Quinazolines: Recent Advances

Frontiers in Chemistry, Journal Year: 2021, Volume and Issue: 8

Published: Jan. 14, 2021

In medicinal chemistry, one of the most significant heterocyclic compounds are quinazolines, possessing broad range biological properties such as anti-bacterial, anti-fungal, anti-HIV, anti-cancer, anti-inflammatory, and analgesic potencies. Owing to its numerous potential applications, in past two decades, there is an increase importance designing novel exploring promising routes synthesize investigating different seeking for applications quinazolines. The present review article describes synthesis quinazolines via eco-friendly, mild, atom-efficient, multi-component synthetic strategies reported literature. discussion divided into parts per key methods involved formation quinazoline skeletons, aiming provide readers effective methodology a better understanding. Consideration has been taken cover recent references. Expectedly, will be advantageous future research synthesizing developing more approaches.

Language: Английский

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Recent advances in quinazolinones as an emerging molecular platform for luminescent materials and bioimaging

Organic Chemistry Frontiers, Journal Year: 2021, Volume and Issue: 8(8), P. 1867 - 1889

Published: Jan. 1, 2021

This review summarized recent advances relating to the luminescence properties of quinazolinones and their applications in fluorescent probes, biological imaging luminescent materials. Their future outlook is also included.

Language: Английский

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