The Journal of Organic Chemistry,
Journal Year:
2019,
Volume and Issue:
84(3), P. 1630 - 1639
Published: Jan. 4, 2019
A
catalyst
and
additive-free
annulation
of
2-pyridylacetates
ynals
under
molecular
oxygen
was
the
first
developed,
affording
3-acylated
indolizines
in
good
to
excellent
yields.
Molecular
used
as
source
carbonyl
atom
indolizines.
This
approach
compatible
with
a
wide
range
functional
groups,
especially
it
has
been
successfully
extended
unsaturated
double
bonds
triple
bonds,
which
were
difficult
prepare
by
previous
methods
single
step.
Organic Letters,
Journal Year:
2021,
Volume and Issue:
23(24), P. 9480 - 9484
Published: Dec. 7, 2021
A
dual
gold/silver-catalyzed
cascade
C(sp3)-H
alkynylation/iminoauration
of
2-substituted
pyridines
with
hypervalent
iodine(III)
reagents
for
the
synthesis
indolizines
is
described.
This
novel
reaction
involves
formation
an
alkynyl
Au(III)
species,
a
functionalization,
and
subsequent
iminoauration
process.
number
bearing
diverse
functionalities
were
prepared
in
good
to
excellent
yield.
Furthermore,
gram-scale
was
efficiently
conducted.
Organic Chemistry Frontiers,
Journal Year:
2022,
Volume and Issue:
9(18), P. 4990 - 4997
Published: Jan. 1, 2022
An
environmentally
benign
electrooxidative
approach
to
the
intramolecular
aminooxygenation
of
alkynes
through
an
electrophilic
cyclization
reaction
has
been
developed,
providing
efficient
toward
diverse
formyl-
and
acyl-substituted
indolizines.
The Journal of Organic Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 19, 2025
A
straightforward
and
efficient
strategy
for
the
synthesis
of
fully
functionalized
indolizines
has
been
developed
through
a
transition
metal-
oxidant-free
[3
+
2]
cycloaddition
reaction
zwitterionic
ketenimines
pyridinium
salts.
This
versatile
method
proceeds
under
mild
conditions,
affording
in
moderate
to
good
yields.
approach
involves
an
intermolecular
cycloaddition,
followed
by
enamine/imine
tautomerization
aromatization.
Notably,
this
demonstrates
broad
functional
group
compatibility
allows
facile
scalability,
making
it
valuable
tool
indolizine-based
frameworks
organic
medicinal
chemistry.
Organic Letters,
Journal Year:
2018,
Volume and Issue:
20(24), P. 7884 - 7887
Published: Dec. 5, 2018
Cp*Co(III)-catalyzed
synthesis
of
cyclopenta[b]carbazoles
from
1-(pyridin-2-yl)-indoles
and
diynes
is
developed.
This
reaction
involves
dual
C–H
activation
indoles
domino
cyclizations
with
has
excellent
regioselectivity,
high
efficiency,
a
broad
substrate
scope,
tolerance
for
various
functional
groups.
A
series
cyclopenta[b]carbazole
molecular
scaffolds
are
obtained
in
good
to
yields.
The Journal of Organic Chemistry,
Journal Year:
2019,
Volume and Issue:
84(3), P. 1630 - 1639
Published: Jan. 4, 2019
A
catalyst
and
additive-free
annulation
of
2-pyridylacetates
ynals
under
molecular
oxygen
was
the
first
developed,
affording
3-acylated
indolizines
in
good
to
excellent
yields.
Molecular
used
as
source
carbonyl
atom
indolizines.
This
approach
compatible
with
a
wide
range
functional
groups,
especially
it
has
been
successfully
extended
unsaturated
double
bonds
triple
bonds,
which
were
difficult
prepare
by
previous
methods
single
step.
