Chemical Communications,
Journal Year:
2018,
Volume and Issue:
54(74), P. 10405 - 10414
Published: Jan. 1, 2018
Recent
advances
in
the
sulfonylation
of
alkenes
via
insertion
sulfur
dioxide
are
summarized.
The
surrogate
DABCO·(SO2)2
or
inorganic
sulfites
is
used
transformation
through
a
radical
process.
Two
strategies
for
with
have
been
developed.
In
most
cases,
vicinal
difunctionalization
initiated
by
arylsulfonyl
generated
situ.
Although
efficient,
asymmetric
versions
still
challenging
and
less
to
be
explored.
It
expected
that
will
developed
rapidly
near
future.
Angewandte Chemie International Edition,
Journal Year:
2017,
Volume and Issue:
57(3), P. 814 - 817
Published: Nov. 22, 2017
Abstract
Transition‐metal‐free
radical
α‐perfluoroalkylation
with
the
accompanying
vicinal
β‐alkenylation
of
unactivated
alkenes
is
presented.
These
cascades
proceed
by
means
1,4‐
or
1,5‐alkenyl
migration
electron
catalysis
on
readily
accessed
allylic
alcohols.
The
reactions
comprise
a
regioselective
perfluoroalkyl
addition
subsequent
alkenyl
and
concomitant
deprotonation
to
generate
ketyl
anion
that
sustains
chain
as
single‐electron‐transfer
reducing
reagent.
Chemical Reviews,
Journal Year:
2021,
Volume and Issue:
121(20), P. 12548 - 12680
Published: Aug. 13, 2021
As
the
"chemical
chameleon",
sulfonyl-containing
compounds
and
their
variants
have
been
merged
with
various
types
of
reactions
for
efficient
construction
diverse
molecular
architectures
by
taking
advantage
incredible
reactive
flexibility.
Currently,
involvement
in
radical
transformations,
which
sulfonyl
group
typically
acts
as
a
leaving
via
selective
C–S,
N–S,
O–S,
S–S,
Se–S
bond
cleavage/functionalization,
has
facilitated
new
formation
strategies
are
complementary
to
classical
two-electron
cross-couplings
organometallic
or
ionic
intermediates.
Considering
great
influence
synthetic
potential
these
novel
avenues,
we
summarize
recent
advances
this
rapidly
expanding
area
discussing
reaction
designs,
substrate
scopes,
mechanistic
studies,
limitations,
outlining
state-of-the-art
processes
involved
radical-mediated
desulfonylation
related
transformations.
With
specific
emphasis
on
applications,
believe
review
will
be
useful
medicinal
organic
chemists
who
interested
chemistry
particular.
Beilstein Journal of Organic Chemistry,
Journal Year:
2021,
Volume and Issue:
17, P. 771 - 799
Published: April 6, 2021
The
reversible,
weak
ground-state
aggregate
formed
by
dipole–dipole
interactions
between
an
electron
donor
and
acceptor
is
referred
to
as
electron-donor–acceptor
(EDA)
complex.
Generally,
upon
light
irradiation,
the
EDA
complex
turns
into
excited
state,
causing
transfer
give
radicals
initiate
subsequent
reactions.
Besides
external
energy
source,
reactions
involving
participation
of
complexes
are
mild,
obviating
transition
metal
catalysts
or
photosensitizers
in
majority
cases
line
with
theme
green
chemistry.
This
review
discusses
synthetic
concerned
well
mechanisms
that
have
been
shown
over
past
five
years.
Chemical Society Reviews,
Journal Year:
2022,
Volume and Issue:
51(15), P. 6774 - 6823
Published: Jan. 1, 2022
Sulfones
are
excellent
candidates
for
the
design
of
new
C–C
and
C–X
bond-forming
reactions
owing
to
easy
activation
C–S
bonds.
This
review
focuses
on
challenges
recent
opportunities
catalytic
functionalization
sulfones.
Advanced Synthesis & Catalysis,
Journal Year:
2023,
Volume and Issue:
365(10), P. 1538 - 1564
Published: March 6, 2023
Abstract
Quaternary
pyridinium
compounds
are
valuable
intermediates
in
organic
synthesis,
which
have
gained
immense
popularity
the
synthetic
community.
The
application
of
transition
metal
or
photoredox
catalysis
transforming
quaternary
into
various
C−C
and
C−X
bonds
is
well
established.
A
majority
these
methods
require
high
temperatures,
expansive
catalysts,
delicate
conditions
for
successful
execution.
On
other
hand,
use
metal‐free
photocatalysis‐free
strategies
constructing
using
derivatives
has
been
sought‐after.
In
this
context,
electron‐donor‐acceptor
(EDA)‐complex
reactions
emerged
as
a
state‐of‐the‐art
methodology,
do
not
any
photocatalyst
their
EDA‐complex
photochemistry
takes
advantage
electron‐acceptor
ability
derivatives,
can
quickly
generate
radical
precursor
via
deaminative
process.
These
newly
generated
useful
several
transformations.
We
hereby,
review,
discuss
an
area
major
progress
mediated
involving
with
mechanism,
substrate
scope,
limitations.
magnified
image
National Science Review,
Journal Year:
2017,
Volume and Issue:
4(3), P. 303 - 325
Published: May 1, 2017
Abstract
The
new
millennium
has
witnessed
the
rapid
development
of
synthetic
organofluorine
chemistry
all
over
world,
and
chemists
in
China
have
made
significant
contributions
this
field.
This
review
aims
to
provide
a
brief
introduction
China's
primary
innovations
from
2000
early
2017,
covering
fluorination,
fluoroalkylation,
fluoromethylthiolation,
fluoroolefination
polyfluoroarylation,
as
well
synthesis
with
fluorinated
building
blocks.
Recent
advances
difluorocarbene
carbon–fluorine
bond
activation
are
also
discussed.
As
conclusion,
ends
some
personal
perspectives
on
future
chemistry.
Journal of the American Chemical Society,
Journal Year:
2018,
Volume and Issue:
140(35), P. 10965 - 10969
Published: Aug. 22, 2018
A
novel
enantioselective
copper-catalyzed
trifluoromethylalkynylation
of
styrenes,
proceeding
through
a
radical
relay
process,
is
described
herein,
which
affords
structurally
diverse
CF3-containing
propargylic
compounds
in
good
yield
with
excellent
enantioselectivities
under
very
mild
conditions.
In
addition,
the
reaction
features
wide
substrate
scope
and
functional
group
tolerance.
Moreover,
trifluoromethylalkynylated
products
can
be
easily
converted
into
synthetically
useful
chiral
terminal
alkynes,
allenes,
Z-alkenes,
as
well
CF3-modified
nonsteroidal
anti-inflammatory
drugs.
