Chemical Communications,
Journal Year:
2018,
Volume and Issue:
54(39), P. 4927 - 4930
Published: Jan. 1, 2018
A
cobalt-catalyzed
oxidative
coupling
of
benzoic
hydrazides
with
maleimides
by
utilizing
2-(1-methylhydrazinyl)pyridine
as
a
bidentate
directing
group
has
been
developed.
This
C-H
functionalization/spirocyclization
cascade
protocol
shows
high
efficiency
and
remarkable
functional
tolerance,
the
ubiquitous
spirosuccinimides
were
obtained
in
good
to
excellent
yields
regioselectivity.
strategy
also
provides
novel
efficient
access
diverse
symmetric
unsymmetrical
bisspirosuccinimides.
ACS Catalysis,
Journal Year:
2018,
Volume and Issue:
8(11), P. 10173 - 10179
Published: Oct. 2, 2018
A
ruthenium-catalyzed
cross-dehydrogenative
coupling
is
developed
with
the
aid
of
a
weakly
coordinating
carboxylic
acid
group
toward
dimerization
arene
acids.
The
protocol
operationally
simple
and
suitable
to
fabricate
diverse
homodimerized
as
well
cross-dimerized
products
in
high
yields.
Computational
insights
have
also
been
unveiled
comprehend
plausible
reaction
mechanism.
critical
innovation
synthetic
strategy
hinges
on
soluble
basic
additive
DBU,
which
constitutes
synergy
Ru(II)-catalysis
noncovalent
interaction
and,
thus,
stabilizes
pivotal
intermediates
promote
challenging
process.
Organic Letters,
Journal Year:
2018,
Volume and Issue:
20(16), P. 4934 - 4937
Published: Aug. 1, 2018
A
highly
selective
and
switchable
ruthenium-catalyzed
ortho
C–H
alkylation
alkenylation
of
benzoic
acids
with
allyl
alcohols
is
reported.
complete
switch
in
selectivity
achieved
upon
tuning
the
reactivity
organometallic
intermediate
carboxylate-directed
activation
to
provide
access
useful
motifs
such
as
2-alkylbenzoic
phthalides.
Organic & Biomolecular Chemistry,
Journal Year:
2020,
Volume and Issue:
18(16), P. 3093 - 3097
Published: Jan. 1, 2020
Switchable
Rh(iii)-catalyzed
highly
regioselective
hydroarylation
and
oxidative
arylation
of
maleimides
with
2-arylindazoles
via
C–H
activation
have
been
demonstrated.
