Rhodium-catalyzed enantioselective annulation of N-phenoxyacetamides with 1,3-dienes DOI
Hui Yang, Ziqi Yang,

Suzhen Zhang

et al.

Science China Chemistry, Journal Year: 2023, Volume and Issue: 66(10), P. 2842 - 2846

Published: June 6, 2023

Language: Английский

Synthesis of Indolyl-Tethered Spiro[cyclobutane-1,1′-indenes] through Cascade Reactions of 1-(Pyridin-2-yl)-1H-indoles with Alkynyl Cyclobutanols DOI

Yuanshuang Xu,

Caiyun Yu, Xinying Zhang

et al.

Organic Letters, Journal Year: 2021, Volume and Issue: 23(21), P. 8510 - 8515

Published: Oct. 15, 2021

Presented herein is an efficient and unprecedented synthesis of indolyl-tethered spiro[cyclobutane-1,1'-indenes] through the cascade reaction 1-(pyridin-2-yl)-1H-indoles with alkynyl cyclobutanols. Mechanistic experiments implicate a sequential process in which 1-(pyridin-2-yl)-1H-indole first undergoes alkenylation cyclobutanol followed by intramolecular Friedel-Crafts to give title products. The utility this novel protocol was reflected ample substrate scope, high chemo- regioselectivity, removable directing group, scalable preparation. In addition, product thus obtained can be further derivatized quite efficiently.

Language: Английский

Citations

17
Hydroxy Group-Enabled Regio- and Stereoselective Hydroalkylation of Alkynyl Cyclobutanol via Palladium-Catalyzed C–C Bond Activation of Cyclopropanol: A One-Step Access to Vinyl Cyclobutanols DOI
Lamphiza O. Najiar, Bedadyuti Vedvyas Pati, Gopal Krushna Das Adhikari

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: 26(30), P. 6314 - 6319

Published: July 22, 2024

The regio-/stereoselective synthesis of vinyl cyclobutanols from alkynyl is demonstrated. Here, selective C-C bond activation the cyclopropyl alcohol ring has been achieved in presence cyclobutanol ring. KIE experiments indicated noninvolvement O-H oxidative addition step rate-determining step. Further, applicability these for 1,4-diketones and 1,6-diketone

Language: Английский

Citations

2
Solvent-free and room temperature microwave-assisted direct C7 allylation of indolines via sequential C–H and C–C activation DOI Creative Commons
Qiuling Wang, Linlin Shi, Shuang Liu

et al.

RSC Advances, Journal Year: 2020, Volume and Issue: 10(18), P. 10883 - 10887

Published: Jan. 1, 2020

A Ru or Rh-catalyzed direct C7 allylation of indolines with vinylcyclopropanes via sequential C–H/C–C activation under microwave irradiation has been disclosed.

Language: Английский

Citations

18
Regiodivergent C−H Annulation of Imines with Unsymmetrical Alkynes Using Transient Directing Alcohols via Rh(III) Catalysis DOI

Bairong Liu,

Yabo Chen,

Qixin Liang

et al.

Advanced Synthesis & Catalysis, Journal Year: 2023, Volume and Issue: 365(12), P. 2018 - 2025

Published: May 20, 2023

Abstract Regiodivergent [3+2] and [4+2] C−H annulation of imines imidate esters with unsymmetrical alkynes has been achieved under Rh(III) catalysis. Further transformation the aldehyde TMS functionality on indene products is also demonstrated. The current work highlights alcohols‐directed multiple esters, leading to diverse fused heterocycles.

Language: Английский

Citations

6
Rhodium-catalyzed enantioselective annulation of N-phenoxyacetamides with 1,3-dienes DOI
Hui Yang, Ziqi Yang,

Suzhen Zhang

et al.

Science China Chemistry, Journal Year: 2023, Volume and Issue: 66(10), P. 2842 - 2846

Published: June 6, 2023

Language: Английский

Citations

6