Asian Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 30, 2024
Abstract
An
efficient,
practical,
and
scalable
Cs
2
CO
3
‐catalyzed
[4+2]
annulation
reaction
between
ynones
acetates
is
presented,
wherein
serve
as
the
four‐atom
partners.
This
methodology
facilitates
synthesis
of
substituted
2‐pyrones
with
yields
ranging
from
good
to
excellent.
The
ready
availability
starting
materials,
coupled
simplicity
protocol,
renders
this
approach
highly
amenable
preparation
a
diverse
range
2‐pyrones.
Furthermore,
feasibility
on
gram
scale
its
application
in
potent
selective
cyclooxygenase‐2
inhibitor
underscore
practical
significance
utility
method.
The Journal of Organic Chemistry,
Journal Year:
2022,
Volume and Issue:
87(21), P. 14005 - 14015
Published: Oct. 10, 2022
A
facile
and
effective
tandem
reaction
of
ynones
methyl
salicylates
was
developed
to
obtain
a
broad
range
3-acyl
chromones
in
moderate-to-excellent
yields.
This
protocol
underwent
Michael
addition
cyclization
process,
which
exhibited
easily
accessible
substrates,
substrate
scope,
high
regioselectivity
under
mild
transition-metal-free
conditions.
Moreover,
gram-scale
further
chemical
transformation
the
products
were
also
studied.
Organic Reaction Mechanisms/Organic reaction mechanisms,
Journal Year:
2023,
Volume and Issue:
unknown, P. 519 - 554
Published: Jan. 20, 2023
A
review
of
pericyclic
biosynthetic
reactions
reports
that
there
are
many
'pericyclase'
enzymes
in
nature
catalyse
such
transformations.
Using
the
Cope
rearrangement
as
a
model
process,
report
shows
synergy
between
acceptor
and
donor
groups
can
allow
rational
design
interrupted
aborted
reactions.
The
Brandi–Guarna
5-spirocyclopropane
isoxazolidines
has
been
investigated
by
computational
methods
to
rationalize
competing
formation
tetrahydropyridones
enaminones.
Nazarov
cyclization
reported
give
substituted
cyclopentenones
with
iodine
catalyst.
thermal
Overman
enantioenriched
cyclic
allylic
alcohols
tertiary
amines.
Ring
expansion
situ
generated
cyclopropylmethyl
cations
via
Wagner–Meerwein
cyclobutanes
involve
planar
cation
loss
chiral
information
case
precursors.
Organic & Biomolecular Chemistry,
Journal Year:
2023,
Volume and Issue:
21(9), P. 2001 - 2014
Published: Jan. 1, 2023
Excellent
diastereoselective
access
to
spirobenzo[
b
]oxepines
via
a
[5
+
2]
spirocyclization
reaction
of
ortho
-hydroxyacetophenones
and
2-aroyl-1-chlorocyclopropanecarboxylates
triggered
by
Cs
2
CO
3
was
developed.
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(16), P. 11567 - 11575
Published: Aug. 1, 2024
An
effective
and
straightforward
Ag(I)-mediated
annulation
of
2-(2-enynyl)quinolines
N'-(2-alkynylbenzylidene)hydrazides
was
developed,
forging
various
synthetically
challenging
17bH-isoquinolino[2'',1'':1′,6']pyridazino[4′,5′:3,4]pyrrolo[1,2-a]quinolines,
including
different
nitrogen-containing
fused
rings,
in
moderate
to
excellent
yields.
This
one-pot
cycloaddition
strategy
features
exclusive
regioselectivity,
high
atom
economy,
broad
substrate
scope
under
mild
conditions.
The
practicality
reliability
this
reaction
demonstrated
by
a
successful
scale-up
synthesis.
Asian Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 30, 2024
Abstract
An
efficient,
practical,
and
scalable
Cs
2
CO
3
‐catalyzed
[4+2]
annulation
reaction
between
ynones
acetates
is
presented,
wherein
serve
as
the
four‐atom
partners.
This
methodology
facilitates
synthesis
of
substituted
2‐pyrones
with
yields
ranging
from
good
to
excellent.
The
ready
availability
starting
materials,
coupled
simplicity
protocol,
renders
this
approach
highly
amenable
preparation
a
diverse
range
2‐pyrones.
Furthermore,
feasibility
on
gram
scale
its
application
in
potent
selective
cyclooxygenase‐2
inhibitor
underscore
practical
significance
utility
method.
