ChemSusChem,
Journal Year:
2020,
Volume and Issue:
13(4), P. 668 - 671
Published: Jan. 9, 2020
Abstract
Aqueous
glycerol
was
identified
as
a
renewable
reaction
medium
for
metalla‐electrocatalyzed
C−H
activation
powered
by
sustainable
energy
sources.
The
solvent
employed
cobalt‐catalyzed
C−H/N−H
functionalizations
under
mild
conditions.
cobalta‐electrocatalysis
manifold
occurred
with
high
levels
of
chemo‐
and
positional
selectivity
allowed
electrochemical
activations
broad
substrate
scope.
resource
economy
this
strategy
considerably
substantiated
the
direct
use
solar
wind
energy.
Organic Letters,
Journal Year:
2021,
Volume and Issue:
23(3), P. 727 - 733
Published: Jan. 8, 2021
Herein,
we
report
the
additive-controlled
divergent
synthesis
of
tetrasubstituted
1,3-enynes
and
alkynylated
3H-pyrrolo[1,2-a]indol-3-ones
through
rhodium-catalyzed
C-H
alkenylation/DG
migration
[3+2]
annulation,
respectively.
This
protocol
features
rare
directing
group
in
1,3-diyne-involved
activation,
excellent
regio-
stereoselectivity,
monofunctionalization
over
difunctionalization,
broad
substrate
scope,
moderate
to
high
yields,
good
functional
compatibility,
mild
redox-neutral
conditions.
Organic Letters,
Journal Year:
2023,
Volume and Issue:
25(31), P. 5896 - 5901
Published: July 29, 2023
A
Cu-electrocatalytic
azidation
of
N-aryl
enamines
and
subsequent
denitrogenative
annulation
for
the
construction
quinoxaline
frameworks
is
reported.
Only
0.5
mol
%
copper(II)
chloride
was
employed
this
cascade
transformation
displaying
excellent
functional-group
compatibility
even
with
complex
bioactive
scaffolds.
The
efficient
electro-oxidative
protocol
enables
use
NaN3
as
cheapest
azide
source.
Detailed
mechanistic
experiments,
cyclic
voltammetry,
spectroscopic
studies
provided
strong
evidence
a
dual
role
Cu
catalyst
in
azidyl
iminyl
radical
generation
steps.
Organic Letters,
Journal Year:
2023,
Volume and Issue:
25(34), P. 6240 - 6245
Published: Aug. 18, 2023
Herein,
the
atroposelective
construction
of
isoquinolinones
bearing
a
C-N
chiral
axis
has
been
successfully
developed
via
Co-catalyzed
C-H
bond
activation
and
annulation
process.
This
conversion
can
be
effectively
carried
out
in
an
environmentally
friendly
oxygen
atmosphere
to
generate
target
axially
frameworks
with
excellent
reactivities
enantioselectivities
(up
>99%
ee)
absence
any
additives.
Additionally,
current
protocol
proved
alternative
approach
for
axial
architectures
fabrication
under
electrochemical
conditions
cobalt/Salox
catalysis,
this
strategy
allowed
efficient
atom-economical
synthesis
various
mild
reaction
conditions.
Organic Letters,
Journal Year:
2020,
Volume and Issue:
22(19), P. 7480 - 7485
Published: Sept. 16, 2020
An
efficient
cobalt-catalyzed
[4
+
2]
annulation
of
hydrazones
and
1,3-diynes
has
been
developed
for
the
synthesis
3-alkynylated
isoquinolines
engaging
2-aminopyridine
as
a
traceless
bidentate
directing
group.
The
strategy
successfully
extended
3,3′-biisoquinoline
moieties
via
both
one-pot
well
sequential
approaches.
utilization
group
with
an
inexpensive
earth-abundant
cobalt-catalyst
under
operationally
simple
reaction
conditions
makes
present
transformation
more
valuable
appealing.
ChemSusChem,
Journal Year:
2020,
Volume and Issue:
13(4), P. 668 - 671
Published: Jan. 9, 2020
Abstract
Aqueous
glycerol
was
identified
as
a
renewable
reaction
medium
for
metalla‐electrocatalyzed
C−H
activation
powered
by
sustainable
energy
sources.
The
solvent
employed
cobalt‐catalyzed
C−H/N−H
functionalizations
under
mild
conditions.
cobalta‐electrocatalysis
manifold
occurred
with
high
levels
of
chemo‐
and
positional
selectivity
allowed
electrochemical
activations
broad
substrate
scope.
resource
economy
this
strategy
considerably
substantiated
the
direct
use
solar
wind
energy.
