Recent advances in nanoparticle-mediated antibacterial applications

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 482, P. 215075 - 215075

Published: Feb. 21, 2023

Language: Английский

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Progress in nanomaterial-based synergistic photothermal-enhanced chemodynamic therapy in combating bacterial infections

Progress in Materials Science, Journal Year: 2024, Volume and Issue: 144, P. 101292 - 101292

Published: April 6, 2024

The prevalence of multidrug-resistant (MDR) bacterial infections has emerged as a serious threat to clinical treatment and global human health, become one the most important challenges in therapy. Hence, there is an urgent need develop safe, effective, new antibacterial strategies based on multifunctional nanomaterials for accurate detection MDR infections. Chemodynamic therapy (CDT) emerging therapeutic strategy that uses Fenton/Fenton-like metal-based nanocatalysts convert hydrogen peroxide (H2O2) into hydroxyl radicals (OH) destroy Despite enormous potential CDT, single CDT limitations such low catalytic efficacy insufficient production H2O2. In this regard, can be combined with other strategies, photothermal (PTT), which effectively enhanced by PTT heating effect. Thus, rational combination nanoplatform been demonstrated highly efficient achieving better This review summarizes discusses latest advances photothermal-enhanced (PT/CDT) infection theranostics well advantages, challenges, future research directions applications, will inspire development PT/CDT

Language: Английский

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Nanozyme-Engineered Hydrogels for Anti-Inflammation and Skin Regeneration

Nano-Micro Letters, Journal Year: 2024, Volume and Issue: 16(1)

Published: Feb. 6, 2024

Inflammatory skin disorders can cause chronic scarring and functional impairments, posing a significant burden on patients the healthcare system. Conventional therapies, such as corticosteroids nonsteroidal anti-inflammatory drugs, are limited in efficacy associated with adverse effects. Recently, nanozyme (NZ)-based hydrogels have shown great promise addressing these challenges. NZ-based possess unique therapeutic abilities by combining benefits of redox nanomaterials enzymatic activity water-retaining capacity hydrogels. The multifaceted effects include scavenging reactive oxygen species other inflammatory mediators modulating immune responses toward pro-regenerative environment enhancing regenerative potential triggering cell migration differentiation. This review highlights current state art NZ-engineered (NZ@hydrogels) for regeneration applications. It also discusses underlying chemo-mechano-biological mechanisms behind their effectiveness. Additionally, challenges future directions this ground, particularly clinical translation, addressed. insights provided aid design engineering novel hydrogels, offering new possibilities targeted personalized skin-care therapies.

Language: Английский

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Designing Composite Stimuli-Responsive Hydrogels for Wound Healing Applications: The State-of-the-Art and Recent Discoveries

Materials, Journal Year: 2024, Volume and Issue: 17(2), P. 278 - 278

Published: Jan. 5, 2024

Effective wound treatment has become one of the most important challenges for healthcare as it continues to be leading causes death worldwide. Therefore, care technologies significantly evolved in order provide a holistic approach based on various designs functional dressings. Among them, hydrogels have been widely used due their biocompatibility and similarity extracellular matrix. The hydrogel formula offers control an optimal moisture level its ability absorb excess fluid from or release needed. Additionally, can successfully integrated with plethora biologically active components (e.g., nanoparticles, pharmaceuticals, natural extracts, peptides), thus enhancing performance resulting composite healing applications. In this review, the-state-of-the-art discoveries related stimuli-responsive hydrogel-based dressings summarized, taking into account antimicrobial, anti-inflammatory, antioxidant, hemostatic properties, well other effects re-epithelialization, vascularization, restoration tissue) use.

Language: Английский

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Machine Learning Enables Highly Accurate Predictions of Photophysical Properties of Organic Fluorescent Materials: Emission Wavelengths and Quantum Yields

Journal of Chemical Information and Modeling, Journal Year: 2021, Volume and Issue: 61(3), P. 1053 - 1065

Published: Feb. 23, 2021

The development of functional organic fluorescent materials calls for fast and accurate predictions photophysical parameters processes such as high-throughput virtual screening, while the task is challenged by limitations quantum mechanical calculations. We establish a database covering >4300 solvated dyes with 3000 distinct compounds develop new machine learning approach aimed at efficient emission wavelength photoluminescence yield (PLQY). Our feature engineering has given rise to functionalized structure descriptor (FSD) comprehensive general solvent (CGSD), whereby highly black-box computational framework realized consistently good accuracy across different dye families, ability describing substitution effects effects, efficiency large-scale predictions, workability on-the-fly learning. Evaluations unseen molecules suggest remarkable mean absolute error 0.13 PLQY 0.080 eV energy, latter comparable time-dependent density theory (TD-DFT) An online prediction platform was constructed based on ensemble model make in various solvents. statistical methodology will complement calculations an alternative these parameters.

Language: Английский

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Hybrid Ag nanoparticles/polyoxometalate-polydopamine nano-flowers loaded chitosan/gelatin hydrogel scaffolds with synergistic photothermal/chemodynamic/Ag+ anti-bacterial action for accelerated wound healing

International Journal of Biological Macromolecules, Journal Year: 2022, Volume and Issue: 221, P. 135 - 148

Published: Aug. 25, 2022

Language: Английский

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Infection microenvironment-activated core-shell nanoassemblies for photothermal/chemodynamic synergistic wound therapy and multimodal imaging

Acta Biomaterialia, Journal Year: 2022, Volume and Issue: 143, P. 445 - 458

Published: Feb. 27, 2022

Language: Английский

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The antibacterial activity of fluoroquinolone derivatives: An update (2018–2021)

European Journal of Medicinal Chemistry, Journal Year: 2021, Volume and Issue: 224, P. 113741 - 113741

Published: Aug. 2, 2021

Language: Английский

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Advances in image-guided drug delivery for antibacterial therapy

Advanced Drug Delivery Reviews, Journal Year: 2022, Volume and Issue: 192, P. 114634 - 114634

Published: Nov. 28, 2022

Language: Английский

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Antimicrobial Photodynamic Therapy for the Remote Eradication of Bacteria

ChemPlusChem, Journal Year: 2023, Volume and Issue: 88(3)

Published: Feb. 28, 2023

Abstract The emergence of multi‐drug resistant bacteria strains has been an uphill battle in modern healthcare worldwide, due to the increasing difficulty killing them. evolving pathogenicity led researchers searching for more effective antimicrobial therapeutics successfully eliminate them without undesirable consequences human body. In recent years, photodynamic therapy (APDT), obsolete technique cancer treatments, reported eradicate and biofilm‐related infections. principle solely relies on photosensitizers (PSs) generating reactive oxygen species, presence light, destroy pathogens. Thus, it can target a broad spectrum microorganisms, owing indirect interaction between PSs bacteria, resulting less likelihood development drug strains. This review will focus progress APDT last five years some future perspectives APDT. mechanism against biofilms, various used APDT, common multidrug‐resistant be briefly introduced. vivo applications several types bacterial infections that includes periodontitis, wound infections, keratitis, endophthalmitis tuberculosis summarized detail.

Language: Английский

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