Chitosan: A Potential Biopolymer in Drug Delivery and Biomedical Applications

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(4), P. 1313 - 1313

Published: April 21, 2023

Chitosan, a biocompatible and biodegradable polysaccharide derived from chitin, has surfaced as material of promise for drug delivery biomedical applications. Different chitin chitosan extraction techniques can produce materials with unique properties, which be further modified to enhance their bioactivities. Chitosan-based systems have been developed various routes administration, including oral, ophthalmic, transdermal, nasal, vaginal, allowing targeted sustained release drugs. Additionally, used in numerous applications, such bone regeneration, cartilage tissue cardiac corneal periodontal wound healing. Moreover, also utilized gene delivery, bioimaging, vaccination, cosmeceutical Modified derivatives improve biocompatibility resulting innovative promising potentials This article summarizes the recent findings on its application science.

Language: Английский

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Current Research on Zinc Oxide Nanoparticles: Synthesis, Characterization, and Biomedical Applications

Nanomaterials, Journal Year: 2022, Volume and Issue: 12(17), P. 3066 - 3066

Published: Sept. 3, 2022

Zinc oxide nanoparticles (ZnO-NPs) have piqued the curiosity of researchers all over world due to their extensive biological activity. They are less toxic and biodegradable with capacity greatly boost pharmacophore bioactivity. ZnO-NPs most extensively used metal in electronic optoelectronics because distinctive optical chemical properties which can be readily modified by altering morphology wide bandgap. The biosynthesis using extracts therapeutic plants, fungi, bacteria, algae, etc., improves stability biocompatibility many settings, its biofabrication alters physiochemical behavior, contributing potency. As such, as an effective nanocarrier for conventional drugs cost-effectiveness benefits being biocompatible. This article covers a comprehensive review different synthesis approaches including physical, chemical, biochemical, green techniques, also emphasizes biopotency through antibacterial, antifungal, anticancer, anti-inflammatory, antidiabetic, antioxidant, antiviral, wound healing, cardioprotective Green from fungus is given special attention, particular emphasis on extraction precursors reaction conditions, characterization surface particles.

Language: Английский

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Research advances in smart responsive-hydrogel dressings with potential clinical diabetic wound healing properties

Military Medical Research, Journal Year: 2023, Volume and Issue: 10(1)

Published: Aug. 22, 2023

The treatment of chronic and non-healing wounds in diabetic patients remains a major medical problem. Recent reports have shown that hydrogel wound dressings might be an effective strategy for treating due to their excellent hydrophilicity, good drug-loading ability sustained drug release properties. As typical example, hyaluronic acid dressing (Healoderm) has been demonstrated clinical trials improve wound-healing efficiency healing rates foot ulcers. However, the degradation behavior clinically-used cannot adjusted according microenvironment. Due intricacy wounds, antibiotics other medications are frequently combined with practice, although these easily hindered by hostile environment. In this case, scientists created responsive-hydrogel based on microenvironment features (such as high glucose low pH) or external stimuli light magnetic field) achieve controllable release, gel degradation, improvements order overcome issues. These anticipated play significant role therapeutic dressings. Here, we review recent advances towards healing, focus structure design, principle responsiveness, degradation. Last but not least, advantages limitations responsive-hydrogels applications will also discussed. We hope contribute furthering progress hydrogels improved practical application.

Language: Английский

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Developing natural polymers for skin wound healing

Bioactive Materials, Journal Year: 2023, Volume and Issue: 33, P. 355 - 376

Published: Nov. 26, 2023

Natural polymers are complex organic molecules that occur in the natural environment and have not been subjected to artificial synthesis. They frequently encountered various creatures, including mammals, plants, microbes. The aforementioned commonly derived from renewable sources, possess a notable level of compatibility with living organisms, limited adverse effect on environment. As result, they hold considerable significance development sustainable environmentally friendly goods. In recent times, there has advancement investigation potential uses field biomedicine, specifically relation biomaterials exhibit antibacterial antioxidant characteristics. This review provides comprehensive overview prevalent utilized biomedical domain throughout preceding two decades. this paper, we present examination components typical methods for preparation based polymers. Furthermore, summarize application polymer materials each stage skin wound repair. Finally, key findings insights into limitations current elucidate prospects their future field.

Language: Английский

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Carbon Nanoparticles and Their Biomedical Applications

Applied Sciences, Journal Year: 2022, Volume and Issue: 12(15), P. 7865 - 7865

Published: Aug. 5, 2022

This review summarizes the current knowledge on and future applications of carbon nanoparticles in medicine. The nanoparticle family has a large number representatives with unique physicochemical properties that make them good candidates for use clinical best-known (and most researched) include graphene, graphene oxide, nanotubes. main direction involves medical diagnostics, which includes bioimaging detection chemicals or metabolites present body. Since question toxicity not been fully answered, fields therapeutics (drug delivery), regenerative medicine (cell scaffolding, tissue engineering), vaccine production is still under research many vivo studies are ongoing. These preclinical suggest have great potential diagnosis treatment; results show used do significant toxic effects; however, caution needed before introduced into routine practice.

Language: Английский

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Perspectives on recent advancements in energy harvesting, sensing and bio-medical applications of piezoelectric gels

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(17), P. 6191 - 6220

Published: Jan. 1, 2023

This review highlights the recent progress in piezoelectric gels (also known as PiezoGels) comprised of polymers, ceramic oxides and supramolecular materials used for energy harvesting, sensing wound dressing.

Language: Английский

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Electrospun polyvinyl alcohol-chitosan dressing stimulates infected diabetic wound healing with combined reactive oxygen species scavenging and antibacterial abilities

Carbohydrate Polymers, Journal Year: 2023, Volume and Issue: 316, P. 121050 - 121050

Published: May 28, 2023

Language: Английский

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Recent progress in polymeric biomaterials and their potential applications in skin regeneration and wound care management

Journal of Drug Delivery Science and Technology, Journal Year: 2023, Volume and Issue: 82, P. 104319 - 104319

Published: Feb. 27, 2023

Language: Английский

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Enhancing wound healing and minimizing scarring: A comprehensive review of nanofiber technology in wound dressings

Progress in Materials Science, Journal Year: 2024, Volume and Issue: 147, P. 101350 - 101350

Published: Aug. 6, 2024

Wound healing is a complex biological process that, when impaired, can lead to the formation of scars. Electrospun nanofibrous wound dressings have emerged as promising option for promoting scar-free healing. This paper explores role physical, compositional, and chemical cues, each contributing remarkable potential these dressings. The physical properties dressings, such porosity mechanical characteristics, guide cellular behaviors promote vascularization, fostering conducive environment reduced scarring. Furthermore, integration natural polymers that mimic skin's extracellular matrix, known compositional adds another layer complexity As therapeutic agents demonstrated their combat chronic scenarios leading scar formation. However, achieving desired effect hinges on nature controlled release. Therefore, also delves into various loading techniques tailoring release profiles bioactive agents. Although electrospun are viable commercial product remains elusive. gap be attributed lack comprehensive in vivo studies, particularly animal models human

Language: Английский

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Nanozyme-Engineered Hydrogels for Anti-Inflammation and Skin Regeneration

Nano-Micro Letters, Journal Year: 2024, Volume and Issue: 16(1)

Published: Feb. 6, 2024

Inflammatory skin disorders can cause chronic scarring and functional impairments, posing a significant burden on patients the healthcare system. Conventional therapies, such as corticosteroids nonsteroidal anti-inflammatory drugs, are limited in efficacy associated with adverse effects. Recently, nanozyme (NZ)-based hydrogels have shown great promise addressing these challenges. NZ-based possess unique therapeutic abilities by combining benefits of redox nanomaterials enzymatic activity water-retaining capacity hydrogels. The multifaceted effects include scavenging reactive oxygen species other inflammatory mediators modulating immune responses toward pro-regenerative environment enhancing regenerative potential triggering cell migration differentiation. This review highlights current state art NZ-engineered (NZ@hydrogels) for regeneration applications. It also discusses underlying chemo-mechano-biological mechanisms behind their effectiveness. Additionally, challenges future directions this ground, particularly clinical translation, addressed. insights provided aid design engineering novel hydrogels, offering new possibilities targeted personalized skin-care therapies.

Language: Английский

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