Advanced Healthcare Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 30, 2025
Abstract
Hierarchical
porous,
bioactive,
and
biocompatible
scaffolds
with
customizable
multi‐functionality
are
promising
alternatives
for
autografts
allografts
in
bone
tissue
engineering.
Combining
high
internal
phase
emulsion
(HIPE)
templating
additive
manufacturing
provides
possibilities
to
produce
such
multiscale
porous
scaffolds.
3D
printing
of
HIPE
remains
a
challenging
task
due
the
intense
separation
under
shear
extrusion
reported
printability
(P
r
)
either
less
than
or
greater
1.
Tuning
viscoelastic
properties
is
therefore
required
achieve
P
≈1.
This
study
addresses
these
issues
by
preparing
Pickering
HIPEs
using
dual
networks
synergistic
viscous
elastic
properties,
stabilized
Cloisite
30B
interphase.
configuration
enhances
viscoelasticity
achieves
values
close
1
(0.98–1.02).
The
printed
exhibit
trabecular
bone‐like,
hierarchical
interconnected
porosity
(77%–86%).
Computational
simulations
accurately
predict
mechanical,
biological,
degradation
behavior.
Functionalization
Cissus
quadrangularis
bioactivates
scaffolds,
demonstrates
vivo
biocompatibility,
promotes
MC3T3‐E1
adhesion,
proliferation,
accelerates
osteogenesis,
reduces
oxidative
stress
compared
neat
PCL
work
introduces
facile
strategy
“engineering
printability”
regenerative
materials
design
holds
potential
developing
optimized
engineering
Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials,
Journal Year:
2024,
Volume and Issue:
151, P. 106385 - 106385
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(9), P. 5009 - 5009
Published: May 3, 2024
Regenerative
medicine
is
an
interdisciplinary
field
aiming
at
restoring
pathologically
damaged
tissues
and
whole
organs
by
cell
transplantation
in
combination
with
proper
supporting
scaffolds.
Gelatine-based
ones
are
very
attractive
due
to
their
biocompatibility,
rapid
biodegradability,
lack
of
immunogenicity.
composite
hydrogels,
containing
strengthening
agents
improve
modest
mechanical
properties,
have
been
demonstrated
act
as
extracellular
matrices
(ECMs),
thus
playing
a
critical
role
“organ
manufacturing”.
Inspired
the
lysyl
oxidase
(LO)-mediated
process
crosslinking,
which
occurs
nature
reinforce
collagen,
we
recently
developed
versatile
protocol
crosslink
gelatine
B
(Gel
B)
presence
or
absence
LO,
using
properly
synthesized
polystyrene-
polyacrylic-based
copolymers
amine
aldehyde
groups
needed
for
crosslinking
reactions.
Here,
following
slight
modifications,
successfully
crosslinked
Gel
different
conditions,
obtaining
eight
out
nine
compounds
high
yield
(57–99%).
The
determined
degree
percentage
(CP%)
evidenced
CP%
obtained
LO
styrenic
amine-containing
(CP5/DMAA)
acrylic
aldehyde-containing
(CPMA/DMAA)
agents.
ATR-FTIR
analyses
confirmed
chemical
structure
all
compounds,
while
optical
microscopy
cavernous,
crater-like,
labyrinth-like
morphologies
cavities
size
range
15–261
µm.
An
apparent
density
0.10–0.45
g/cm3
aerogel-like
most
samples.
Although
best
biodegradation
profile
was
observed
sample
10%
CP5/DMAA
(M3),
swelling
absorption
porosity,
good
profiles
were
also
samples
5–10%
(M4,
5,
6)
20%
CPMA/DMAA
(M9)
copolymers.
Collectively,
this
work
synthesis
physicochemical
characterization,
new
composites
and,
based
on
characteristics,
fit
well
within
requirements
TE,
five
candidates
(M3,
M4,
M5,
M6,
M9)
suitable
future
biological
experiments
adhesion,
infiltration
proliferation,
confirm
effective
functioning,
identified.
Cureus,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 17, 2024
Theranostics,
a
remarkable
combination
of
diagnostics
and
therapeutics,
has
given
rise
to
tissue/organ-format
theranostic
scaffolds
that
integrate
targeted
therapy
real-time
disease
monitoring.
The
scaffold
is
3D
structuring
template
for
cell
or
tissue
attachment
growth.
These
offer
unprecedented
opportunities
personalized
medicine
hold
great
potential
revolutionizing
healthcare.
Recent
advancements
in
fabrication
techniques
have
enabled
the
creation
highly
intricate
precisely
engineered
with
controllable
physical
chemical
properties,
enhancing
their
therapeutic
engineering
regenerative
medicine.
This
paper
proposes
new
categorization
method
based
on
relativity
design-independent
parameters.
Five
types
are
defined
at
different
levels,
highlighting
importance
understanding
analyzing
types.
It
possesses
ability
seamlessly
therapeutics
within
single
platform,
efficacy
precision
Natural
derived
from
biomaterials
synthetic
fabricated
by
human
intervention
discussed,
offering
advantages
such
as
tunable
mechanical
properties
controlled
drug
delivery,
while
natural
provide
inherent
biocompatibility
bioactivity,
making
them
ideal
promoting
cellular
responses.
use
shows
promise
advancing
improving
patient
outcomes.
transfer
technologies
changes
society
accelerated
evolution
health
monitoring
into
era
personal
Using
emerging
data,
cost-effective
analytics,
wireless
sensor
networks,
mobile
smartphones,
easy
internet
access,
these
expected
accelerate
transition
outside
traditional
healthcare
settings.
main
objective
this
review
article
comprehensive
overview
applications
current
biomedical
research,
dual
role
diagnostics.
aims
explore
latest
design,
fabrication,
functionalization,
emphasizing
how
innovations
contribute
improved
efficacy,
progression
across
various
medical
fields.
ACS Applied Bio Materials,
Journal Year:
2023,
Volume and Issue:
6(12), P. 5596 - 5608
Published: Dec. 5, 2023
Hybrid
collagen
(Coll)
bioscaffolds
have
emerged
as
a
promising
solution
for
tissue
engineering
(TE)
and
regenerative
medicine.
These
innovative
combine
the
beneficial
properties
of
Coll,
an
important
structural
protein
extracellular
matrix,
with
various
other
biomaterials
to
create
platforms
long-term
cell
growth
formation.
The
integration
or
cross-linking
Coll
increases
mechanical
strength
stability
introduces
tailored
biochemical
physical
factors
that
mimic
natural
microenvironment.
This
work
reports
on
fabrication
chemically
cross-linked
hybrid
enhanced
from
combination
nanofibrillated
cellulose
(NFC),
carboxymethylcellulose
(CMC),
citric
acid
(CA).
were
prepared
by
3D
printing
ink
containing
Coll-NFC-CMC-CA
followed
freeze-drying,
dehydrothermal
treatment,
neutralization.
Cross-linking
through
formation
ester
bonds
between
polymers
CA
in
was
achieved
exposing
elevated
temperatures
dry
state.
morphology,
pores/porosity,
chemical
composition,
structure,
thermal
behavior,
swelling,
degradation,
wet
states
investigated
function
concentration.
showed
no
cytotoxicity
MG-63
human
bone
osteosarcoma
cells
tested
different
assays
measuring
end
points.
Overall,
presented
offer
unique
biocompatibility,
stability,
support,
making
them
valuable
tools
TE.
Biomacromolecules,
Journal Year:
2024,
Volume and Issue:
25(9), P. 5512 - 5540
Published: Aug. 12, 2024
Current
bone
repair
methods
have
limitations,
prompting
the
exploration
of
innovative
approaches.
Tissue
engineering
emerges
as
a
promising
solution,
leveraging
biomaterials
to
craft
scaffolds
replicating
natural
environment,
facilitating
cell
growth
and
differentiation.
Among
fabrication
techniques,
three-dimensional
(3D)
printing
stands
out
for
its
ability
tailor
intricate
scaffolds.
Silk
proteins
(SPs),
known
their
mechanical
strength
biocompatibility,
are
an
excellent
choice
3D-printed
tissue
(BTE)
This
article
comprehensively
reviews
biology,
3D
printing,
unique
attributes
SPs,
specifically
detailing
criteria
scaffold
such
composition,
structure,
mechanics,
cellular
responses.
It
examines
structural,
mechanical,
biological
emphasizing
suitability
BTE.
Recent
studies
on
diverse
approaches
using
SPs-based
BTE
highlighted,
alongside
advancements
in
four-dimensional
(4D)
role
osteo-immunomodulation.
Future
directions
use
SPs
outlined.
Materials,
Journal Year:
2025,
Volume and Issue:
18(2), P. 389 - 389
Published: Jan. 16, 2025
Nowadays,
metallic
bone
replacement
is
in
high
demand
due
to
different
issues,
like
sicknesses
and
accidents.
Thus,
implants
are
fabricated
with
tailored
properties
microstructure
for
long-term
use
the
human
body.
To
improve
such
implants,
3D
printing
most
promising
technique.
Therefore,
this
work
aims
evaluate
fabrication
of
porous
materials
by
extrusion
Ti6Al4V.
Cylindrical
samples
were
from
pellets
metal
injection
molding
Ti6Al4V
powders,
creating
hexagonal
channels
three
sizes.
The
densification
kinetics
was
evaluated
dilatometry
tests,
which
enabled
following
during
sintering
cycle.
Subsequently,
characterized
scanning
electron
microscopy
X-ray
computed
tomography
analyze
their
microstructure.
Compression
tests
mechanical
strength
sintered
samples.
It
found
that
shape
better
defined
as
channel
size
increases.
results
show
similar
behavior
each
sizes
sintering;
however,
greater
obtained
decreases.
Additionally,
microporosity
at
particle
level,
completely
interconnected,
ensuring
passage
fluids
through
entire
sample.
On
other
hand,
increases,
Young's
modulus
yield
considerably
reduced.
main
conclusion
parts
two
scales
porosity
can
be
designed
process.
