Small Science,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 16, 2024
Lung
cancer
cells
resistant
to
radiotherapy
present
a
significant
clinical
challenge.
Stable
telomeric
structures,
maintained
by
the
TRF2
protein,
play
critical
role
in
protecting
from
ionizing
radiation.
Reduced
expression
increases
DNA
damage
and
radiosensitivity.
We
designed
self‐assembling
system
utilizing
ultra‐small
luminescent
gold
nanoclusters
(AuNCs)
with
radiosensitizing
properties,
combined
siRNA
targeting
TRF2.
The
forms
≈100
nm
non‐spherical
structures
AuNCs
enriched
outer
layer,
exhibiting
17.6‐fold
enhancement
red
photoluminescence
due
aggregation‐induced
effects.
This
nanoplatform
efficiently
penetrates
lung
cells,
reducing
50%.
Under
5
Gy
radiotherapy,
treated
this
show
1.5‐fold
radiosensitivity
increase
2.3‐fold
reduction
clonogenic
survival
telomere
deprotection.
AuNC‐siRNATRF2
combines
enhanced
optical
properties
biological
functionality,
offering
promising
approach
augment
efficacy
disrupting
protective
mechanisms
cells.
Chemical Reviews,
Journal Year:
2024,
Volume and Issue:
124(11), P. 7262 - 7378
Published: May 2, 2024
Ligand-protected
metal
clusters
possess
hybrid
properties
that
seamlessly
combine
an
inorganic
core
with
organic
ligand
shell,
imparting
them
exceptional
chemical
flexibility
and
unlocking
remarkable
application
potential
in
diverse
fields.
Leveraging
to
expand
the
library
of
available
materials
stimulate
development
new
functionalities
is
becoming
increasingly
pressing
requirement.
This
Review
focuses
on
origin
from
structural
analysis,
including
intra-cluster
bonding,
inter-cluster
interactions,
cluster-environments
metal-to-ligand
ratios,
thermodynamic
effects.
In
introduction,
we
briefly
outline
explain
differences
commonalities
M(I)/M(I/0)
coinage
clusters.
Additionally,
distinguish
bonding
characteristics
atoms
core,
which
give
rise
their
distinct
flexibility.
Section
2
delves
into
categories,
theories
related
following
sections
3
7,
primarily
elucidate
mechanisms
trigger
flexibility,
dynamic
processes
transformation,
resultant
alterations
structure,
ensuing
modifications
physical–chemical
properties.
8
presents
notable
applications
have
emerged
utilizing
assemblies.
Finally,
section
9,
discuss
future
challenges
opportunities
within
this
area.
Molecules,
Journal Year:
2024,
Volume and Issue:
29(7), P. 1574 - 1574
Published: April 1, 2024
Gold
nanoclusters
(Au
NCs)
with
bright
emission
and
unique
chemical
reactivity
characters
have
been
widely
applied
for
optical
sensing
imaging.
With
a
combination
of
surface
modifications,
effective
therapeutic
treatments
tumors
are
realized.
In
this
review,
we
summarize
the
recently
adopted
biosensing
therapy
events
based
on
Au
NCs.
Homogeneous
fluorometric
systems
toward
various
targets,
including
ions,
small
molecules,
reactive
oxygen
species,
biomacromolecules,
cancer
cells,
bacteria,
in
vitro
vivo,
presented
by
turn-off,
turn-on,
ratiometric
tactics.
The
applications
concluded
three
aspects:
photodynamic
therapy,
photothermal
as
drug
carrier.
basic
mechanisms
performances
these
introduced.
Finally,
review
highlights
challenges
future
trend
NC-based
systems.
Chemical & Biomedical Imaging,
Journal Year:
2024,
Volume and Issue:
2(7), P. 462 - 480
Published: June 18, 2024
In
the
realm
of
nanomaterials,
atomically
precise
quasi-molecular
gold
nanoclusters
(AuNCs)
play
a
prime
role
due
to
their
unique,
stable,
and
highly
tunable
optical
properties.
They
are
extensively
structure-engineered
for
modulation
surface
electronic
states
toward
long
wavelength
photoluminescence,
particularly
in
NIR-II
(1000
1700
nm)
window.
Contrast
agents
with
emission
can
potentially
transform
imaging
terms
higher
spatial
resolution,
deeper
tissue
penetration,
reduced
autofluorescence.
These
advantages
allow
real-time
living
organisms
observing
disease
progression
treatment
response.
this
short
review,
we
discuss
origin
rationally
designed
AuNCs
application
high
resolution
vasculatures
hard
soft
structures
identification
pathological
conditions
such
as
stroke
injury.
Further,
recent
employment
these
rapidly
growing
field
tumor
theranostics
is
also
summarized.
Final
remarks
provided
on
scope
improvement
properties
persisting
challenges
clinical
translation.
Molecules,
Journal Year:
2025,
Volume and Issue:
30(3), P. 541 - 541
Published: Jan. 24, 2025
This
study
explores
the
sonocatalytic
activity
of
gold
nanoclusters
(Au
NCs)
combined
with
titanium
dioxide
(TiO2)
nanoparticles,
forming
Au
NCs/TiO2
composites.
The
hybrid
material
significantly
enhances
hydroxyl
radical
(•OH)
generation
under
ultrasonic
conditions,
attributed
to
high-energy
cavitation
bubbles
formed
during
ultrasonication.
effects
frequency
(200,
430,
and
950
kHz)
power
were
systematically
evaluated
on
Au144/TiO2
composites,
identifying
430
kHz
as
optimal
for
•OH
production
due
its
efficient
energy.
Au144
NCs
function
electron
traps,
reducing
electron–hole
recombination
in
ultrasonically
activated
TiO2,
thereby
improving
charge
separation
enhancing
generation.
Size-dependent
also
studied,
showing
an
efficiency
trend
>
Au25
plasmonic
nanoparticles
bare
TiO2.
These
findings
highlight
importance
ultrasonication
NC
size
optimizing
performance
providing
valuable
insights
designing
advanced
sonocatalysts
applications
chemical
synthesis,
environmental
remediation,
biomedical
fields.
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Jan. 6, 2024
Abstract
The
accurate
preoperative
diagnosis
and
tracking
of
lung
adenocarcinoma
is
hindered
by
non-targeting
diffusion
dyes
used
for
marking
tumors.
Hence,
there
an
urgent
need
to
develop
a
practical
nanoprobe
tracing
precisely
even
treating
them
noninvasively.
Herein,
Gold
nanoclusters
(AuNCs)
conjugate
with
thyroid
transcription
factor-1
(TTF-1)
antibody,
then
multifunctional
Au-TTF-1
designed
synthesized,
which
underscores
the
paramount
importance
advancing
machine
learning
bioimaging-guided
treatment
adenocarcinoma.
Bright
fluorescence
(FL)
strong
CT
signal
set
stage
tracking.
Furthermore,
high
specificity
TTF-1
antibody
facilitates
selective
targeting
cells
as
compared
common
epithelial
cells,
so
software
Lung
auxiliary
detection
system
was
designed,
combined
assist
intelligent
recognition
jointly.
Besides,
not
only
contributes
intuitive
targeted
visualization,
but
also
guides
following
noninvasive
photothermal
treatment.
boundaries
tumor
are
light
up
navigation,
it
penetrates
into
implements
treatment,
resulting
in
ablating
tumors
vivo
locally.
Above
all,
serves
key
platform
target
bio-imaging
synergistic
PTT
single
nanoprobe,
demonstrates
attractive
performance
on
Graphical
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
63(32)
Published: May 16, 2024
Gold
nanoclusters
exhibiting
concomitant
photothermy
(PT)
and
photoluminescence
(PL)
under
near-infrared
(NIR)
light
irradiation
are
rarely
reported,
some
fundamental
issues
remain
unresolved
for
such
materials.
Herein,
we
concurrently
synthesized
two
novel
rod-shaped
Au
nanoclusters,
Inorganics,
Journal Year:
2025,
Volume and Issue:
13(3), P. 72 - 72
Published: Feb. 27, 2025
Chiral
gold
nanomaterials
have
promising
applications
in
biomedicine,
catalysis,
optics
and
other
fields.
However,
the
complexity
of
their
chiral
sources
has
led
to
many
challenges
terms
functional
design
controlled
synthesis.
In
this
paper,
we
systematically
review
development
history
Au
nanomaterials;
deeply
analyze
synthesis
strategy,
construction
mechanism,
performance
optimization
pathway;
discuss
formation
mechanism
light
progress
cutting-edge
research
look
into
future
direction
development.
The
aim
is
provide
theoretical
methodological
support
for
controllable
nanomaterials.
