Bacteria-Derived Cellulose Membranes Modified with Graphene Oxide-Silver Nanoparticles for Accelerating Wound Healing
ACS Applied Bio Materials,
Journal Year:
2024,
Volume and Issue:
7(8), P. 5530 - 5540
Published: Aug. 2, 2024
This
study
reports
on
the
modification
of
bacterial
cellulose
(BC)
membranes
produced
by
static
fermentation
Language: Английский
Optimizations of Placenta Extracellular Matrix‐Loaded Silk Fibroin/Alginate 3D‐Printed Scaffolds Structurally and Functionally for Bone Tissue Engineering
Engineering in Life Sciences,
Journal Year:
2025,
Volume and Issue:
25(1)
Published: Jan. 1, 2025
ABSTRACT
Recent
interest
has
been
focused
on
extracellular
matrix
(ECM)–based
scaffolds
totreat
critical‐sized
bone
injuries.
In
this
study,
urea
was
used
to
decellularize
and
solubilize
human
placenta
tissue.
Then,
different
concentrations
of
ECM
were
composited
with
8%
alginate
(Alg)
12%
silk
fibroin
(SF)
for
printing
in
order
produce
a
natural
3D
construct
that
resembled
The
physical
biological
features
the
printed
structures
evaluated
entirely
vitro.
Finally,
rat
model
employed
examine
optimal
scaffold
(5%
ECM)
as
transplant
healing
cranial
lesions.
present
investigation
demonstrated
decellularizing
placental
tissue
fragments
led
efficient
removal
cell
debris.
addition,
remarkable
improvement
scaffolds'
mechanical
properties
observed
by
increasing
concentration.
histology
studies
real‐time
PCR
results
acceleration
regeneration
lesions
treated
5%ECM‐SF/Alg
at
4
8
weeks
after
implantation.
Overall,
these
proved
ECM‐printed
could
potentially
biomimetic
grafts
reconstruct
significant
defects
now
promise
proceed
clinical
studies.
Language: Английский
A review of recent advances in nanotechnology for the delivery of therapeutics in wound healing
Aziz Ullah,
No information about this author
Muneeb Ullah,
No information about this author
Gyu-Jin Lee
No information about this author
et al.
Journal of Pharmaceutical Investigation,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 19, 2024
Language: Английский
The revolutionary role of placental derivatives in biomedical research
Bioactive Materials,
Journal Year:
2025,
Volume and Issue:
49, P. 456 - 485
Published: March 19, 2025
Language: Английский
Engineering of a 3D Printed Bilayer Artificial Skin Bio‐Mimicking Epidermis and Dermis for Skin Tissue Engineering Applications
Mahan Mahdavi,
No information about this author
Azadeh Asefnejad,
No information about this author
Zohreh Bagher
No information about this author
et al.
Polymers for Advanced Technologies,
Journal Year:
2025,
Volume and Issue:
36(4)
Published: April 1, 2025
ABSTRACT
The
limited
strength
and
quick
breakdown
of
amniotic
membrane
(AM)
have
restricted
its
use
in
skin
wound
treatment.
This
research
involved
direct
3D
printing
a
bioink
prepared
from
chitosan
(CTS)
alginate
(Alg)
onto
AM
to
produce
two‐layer
with
enhanced
biomechanical
properties,
allowing
for
the
healing
full‐thickness
wounds.
AM‐CTS/Alg
bilayer
scaffold
was
fully
characterized
vitro
vivo.
suture
retention
tensile
showed
significant
increase
compared
based
on
results.
exhibited
excellent
properties
cytobiocompatibility
cell
attachment
fibroblast
cells.
Additionally,
when
layered
CTS/Alg
printed
scaffold,
degradation
rate
notably
decreased.
In
vivo
studies
revealed
both
supported
healing.
Histological
analysis
treated
wounds
demonstrated
complete
re‐epithelialization,
granulation,
collagen
synthesis,
increased
expression
pro‐angiogenesis
genes
(VEGFa
bFGF)
at
days
10
20
posttreatment
AM‐CTS/Alg.
contrast,
control
persistent
ruptured
unhealed
epithelium.
optimized
demonstrates
itself
as
promising
substitute
possessing
exceptional
biological
characteristics
effective
treatment
Language: Английский
Translation Prospects of a Novel ECM‐Silk Fibroin/Alginate 3D‐Printed Scaffold for Treatment of Full‐Thickness Skin Wounds: An In Vitro and In Vivo Study
Polymers for Advanced Technologies,
Journal Year:
2024,
Volume and Issue:
35(11)
Published: Nov. 1, 2024
ABSTRACT
The
development
of
bioinks
incorporating
extracellular
matrix
(ECM)
has
attracted
significant
interest
for
creating
three‐dimensional
(3D)‐printed
structures
that
simulate
natural
skin,
aiming
to
facilitate
profound
wound
healing.
In
our
study,
we
utilized
the
potential
human
placenta,
renowned
its
abundant
structural
proteins
and
growth
factors
essential
recovery,
as
a
basis
an
ECM‐based
bioink.
Different
concentrations
(1.5%,
3%
5%
w/v)
decellularized/solubilized
placental
ECM
were
integrated
into
silk
fibroin/alginate
generate
printable
biocompatibility
printed
hydrogels
was
studied
in
vitro.
Our
refined
bioink
at
w/v
concentration
administered
full‐thickness
wounds
mouse
model.
frameworks,
due
their
distinct
structure,
created
non‐cytotoxic
environment
conducive
vitro
cell
adhesion,
infiltration,
proliferation.
Crucially,
they
did
not
provoke
adverse
immune
reaction
host.
Implanting
3D‐printed
scaffold
deep
resulted
increased
formation
granulation
tissue,
angiogenesis,
re‐epithelialization
compared
scaffolds
lacking
untreated
wounds.
findings
decisively
demonstrate
3D
promotes
regeneration
vivo,
skin
substitute
with
cellular
organization
closely
resembling
normal
skin.
This
advancement
sets
stage
future
clinical
exploration
holds
tremendous
promise
advancing
healing
therapies.
Language: Английский
Engineering of a bilayer antibacterial wound dressing from bovine pericardium and electrospun chitosan/PVA/antibiotics for infectious skin wounds management: An in vitro and in vivo study
International Journal of Biological Macromolecules,
Journal Year:
2024,
Volume and Issue:
282, P. 137055 - 137055
Published: Nov. 2, 2024
Language: Английский