Advances in Pharmacological and Pharmaceutical Sciences,
Journal Year:
2024,
Volume and Issue:
2024(1)
Published: Jan. 1, 2024
The
treatment
of
human
immunodeficiency
virus
(HIV)
in
children
has
persistently
been
complex
and
tedious
on
a
global
scale.
This
is
because
adult
pediatric
HIV
treatments
follow
similar
therapeutic
approach.
Due
to
the
dearth
clinically
licensed
antiretroviral
drug
(ARVD)
therapy,
with
worldwide
are
prescribed
unlicensed
drugs
each
year.
triggered
likelihood
poor
adherence,
failure,
even
adverse
reactions
brought
by
variety
factors,
including
pill
size
quantity,
which
main
cause
swallowing
difficulties,
repeated
administration
these
various
ARVDs,
many
have
solubility
severe
side
effects
children,
unpalatability
drug,
one
criteria
for
formulations.
Thus,
there
necessity
investigation
into
several
advanced
microencapsulation
techniques
that
could
curb
challenges.
Microencapsulation
explored
delivery
encapsulation
manufacture
different
nanoparticles
shown
significant
potential
mitigating
surmounting
constraints,
such
as
taste
masking,
enhanced
bioavailability,
production
micronized
fine
powders
varying
diseases.
Nevertheless,
usage
technologies
formulations
garnered
relatively
little
attention.
this
review
paid
keen
interest
examining
strategies
utilization
development
International Journal of Biological Macromolecules,
Journal Year:
2024,
Volume and Issue:
unknown, P. 138855 - 138855
Published: Dec. 1, 2024
Plant-derived
bioactive
polysaccharides
(PDBPs),
versatile
polymers
originating
from
various
botanical
sources,
exhibit
a
spectrum
of
biological
functionalities
crucial
for
human
health.
This
review
delves
into
the
multifaceted
roles
these
compounds,
elucidating
their
immune-boosting
properties,
antioxidant
prowess,
anti-inflammatory
capabilities,
and
contributions
to
gut
Amidst
pivotal
roles,
efficiency
PDBPs
delivery
bioavailability
in
system
stands
as
central
determinant
efficacy
utilization.
paper
extensively
systematically
examines
diverse
activities,
such
immunomodulatory
effects,
mechanisms
like
microencapsulation,
promising
applications
within
realms
both
food
(functional
foods
nutraceuticals)
pharmaceutical
(antimicrobial
agents
drugs)
sectors.
Additionally,
it
offers
comprehensive
overview
classification,
structural
diversity
polysaccharides,
highlighting
identification
techniques
rheological
considerations.
Moreover,
addresses
critical
safety
regulatory
concerns
alongside
global
legislation
about
plant
envisaging
broader
landscape
Through
this
synthesis,
we
aim
underscore
holistic
significance
potential
revolutionize
nutritional
therapeutic
paradigms.
Journal of Microencapsulation,
Journal Year:
2024,
Volume and Issue:
41(7), P. 649 - 678
Published: Aug. 12, 2024
This
study
examines
microencapsulation
as
a
method
to
enhance
the
stability
of
natural
compounds,
which
typically
suffer
from
inherent
instability
under
environmental
conditions,
aiming
extend
their
application
in
pharmaceutical
industry.
Future Medicinal Chemistry,
Journal Year:
2024,
Volume and Issue:
16(8), P. 791 - 809
Published: April 4, 2024
This
manuscript
proposes
an
innovative
approach
to
mitigate
the
gastrointestinal
adversities
linked
with
nonsteroidal
anti-inflammatory
drugs
(NSAIDs)
by
exploiting
amylose
as
a
novel
drug
delivery
carrier.
The
intrinsic
attributes
of
V-amylose,
such
its
structural
uniqueness,
biocompatibility
and
biodegradability,
well
capacity
form
inclusion
complexes
diverse
molecules,
are
meticulously
explored.
Through
comprehensive
physicochemical
analysis
V-amylose
ulcerogenic
NSAIDs,
plausibility
protective
carrier
for
NSAIDs
regions
is
elucidated.
review
further
discusses
potential
therapeutic
advantages
amylose-based
systems
in
management
gastric
ulcers.
By
providing
controlled
release
kinetics
enhanced
bioavailability,
these
offer
promising
prospects
development
more
effective
ulcer
therapies.
Langmuir,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 29, 2025
Polymer
Janus
nanoparticles
with
one
hard
cross-linked
polystyrene
lobe
and
soft
film-forming
poly(methyl
methacrylate-co-butyl
acrylate)
were
synthesized
by
reversible
addition-fragmentation
chain
transfer
(RAFT)-mediated
emulsion
polymerization.
The
adsorbed
to
oil/water
air/water
interfaces,
where
the
lobes
coalesced,
forming
films
of
thickness
between
25
250
nm;
droplets
silicone
oil
could
be
stably
encapsulated
in
polymer
this
way.
When
prepared
mechanical
mixing
without
additives,
capsules
diameter
5-500
μm
prepared,
additives
application
heat,
around
5
achieved,
even
highly
viscous
(20,000
cSt).
In
a
microfluidic
device,
monodisperse
180
formed.
particles
weakly
surface-active
spontaneously
assembled
themselves
at
interfaces.
added
into
paint
formula,
improved
stain
resistance
films.
Silicone
leakage
from
mitigated
incubating
silica
nanoparticles,
on
which
reacts,
creating
grafted
layers.
