International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 289, P. 138822 - 138822
Published: Dec. 16, 2024
Language: Английский
International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 3657 - 3675
Published: April 1, 2024
Abstract: Exosomes are extracellular vesicles that originate from various cells and mediate intercellular communication, altering the behavior or fate of recipient cells. They carry diverse macromolecules, such as lipids, proteins, carbohydrates, nucleic acids. Environmental stressors can change exosomal contents many cells, making them useful for diagnosing chronic disorders, especially neurodegenerative, cardiovascular, cancerous, diabetic diseases. Moreover, exosomes be engineered therapeutic agents to modulate disease processes. State-of-art techniques employed separate including ultracentrifugation, size-exclusion chromatography immunoaffinity. However, modern technologies aqueous two-phase system well microfluidics gaining attention in recent years. The article highlighted composition, biogenesis, implications exosomes, standard novel methods isolating applying biomarkers cargo carriers. Keywords: Exosomes, vesicles, biomarkers, carriers, separation
Language: Английский
Citations
12
ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: 7(4), P. 2128 - 2139
Published: April 3, 2024
Cancer research has made significant progress in recent years, and extracellular vesicles (EVs) based cancer investigation reveals several facts about cancer. Exosomes are a subpopulation of EVs. In the present decade, exosomes is mostly highlighted for theranostic research. Tumor cell derived (TEXs) promote but there multiple sources that can be used as therapeutic agents (plant exosomes, stem cell-derived modified or synthetic exosomes). Stem cells regenerative medicine faces numerous challenges, such tumor development, cellular reprogramming etc., therefore addressing these complications becomes essential. serves an answer to problems offers better solution. Global indicates also play dual role system by either inhibiting promoting Modified which genetically engineered surface increase efficacy properties considered target above concerns. However, difficulties associated with include variations heterogenity, isolation protocols, large scale production, have managed effectively. this review, we explore biogenesis, exosome sources, drug delivery, clinical trial related challenges domain future orientation. This article may encourage researchers develop effective affordable
Language: Английский
Citations
11
Macromolecular Rapid Communications, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 21, 2025
Abstract Exosomes, the bioactive particles secreted by various cells, are essential in mediating cellular communication. However, their small size and interference from non‐exosome proteins present significant hurdles for rapid non‐destructive capture release. To overcome these obstacles, a promising strategy to efficiently selectively isolate exosomes mesenchymal stem cells (MSCs) is developed using CD63 aptamer‐conjugated magnetic nanoparticles (Fe 3 O 4 ‐Aptamer). The Fe first modified RAFT polymerization of N ‐(methacryloyloxy) succinimide oligoethylene glycol methacrylate, subsequently, aptamers grafted onto surface produce ‐Aptamer. These aptamer units act as “lock key” recognition with on exosomes, enabling specific binding exosomes. ‐Aptamer can conditioned medium, be easily collected an external field, facilitating facile collection multiple‐cycle reuse By introducing complementary sequence aptamer, captured rapidly released because stronger affinity between aptamers. When utilized exosome isolation, exosome‐capture release efficiency achieve up ca. 82.9% 96.1%, respectively. Thus, offers highly efficient isolation
Language: Английский
Citations
1
Cancers, Journal Year: 2025, Volume and Issue: 17(7), P. 1094 - 1094
Published: March 25, 2025
Oral cancer refers to cancers originating in the oral cavity and oropharyngeal regions. It is 16th most prevalent sixth leading cause of cancer-related deaths. However, mechanisms its progression are still being understood, interventions provide early diagnosis need be improved. More studies have recently been conducted on cancer, many reviews summarized findings this field, focusing individual factors. few review articles evaluated combinational impacts different factors cancer. This aimed an overview effects three extracellular factors, including lifestyle habits, microbiome, socioeconomic progression. differentially affected by habits; high-sugar diets, processed foods, alcohol, smoking, possibly sleep disorders benefit progression, whereas eating natural such as fruits, vegetables, fish, garlic, drinking tea or coffee, physical exercise can combat it. The microbiome could suppress promote Low status impact development. Furthermore, crosstalk among these affects has limitations not all cancer-affecting important publications. focus should placed multiple treatment. study update researchers landscape help formulate approaches prevention
Language: Английский
Citations
0
ACS Omega, Journal Year: 2025, Volume and Issue: unknown
Published: May 5, 2025
Language: Английский
Citations
0
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 289, P. 138822 - 138822
Published: Dec. 16, 2024
Language: Английский
Citations
0