Reprogramming Retinal Microglia Polarization by Efferocytosis-Mimicking Nanoparticles for Ameliorating Diabetic Retinopathy DOI
Zhipeng Li, Wenyu Wang, Liping Zhu

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: May 7, 2025

Diabetic retinopathy (DR), as the most common microvascular complication of diabetes, seriously threatens vision diabetic patients. As resident phagocytes retina, microglia participate in inflammation, neovascularization, and neurodegeneration DR. Herein, apoptotic retinal cell membrane-coated, rapamycin-loaded mesoporous Prussian blue NPs immunomodulators for ameliorating DR by modulating microglial polarization are reported. The apoM@mPB@Ra exhibited favorable stability biocompatibility achieved active targeted delivery due to specific recognition between "eat me" signal expressed on membrane microglia. In an LPS-induced cellular inflammation model, effectively promoted toward anti-inflammatory phenotype (M2) scavenging intracellular reactive oxygen species (ROS) combined with affecting mTOR signaling pathway, leading downregulation pro-inflammatory cytokines IL-6 TNF-α. Meanwhile, owing multienzyme-like activities mPB nanoparticles, obviously alleviated hypoxia, thereby decreasing expression VEGF. Notably, a mouse model DR, intravitreally injected significantly improved severity abnormal vascular network inflammatory microenvironment down-regulating HIF-1α, VEGF, inflammatory-related cytokines. Collectively, these findings demonstrate that provide promising effective approach treatment

Language: Английский

A Comprehensive Review of Stimuli-Responsive Smart Polymer Materials—Recent Advances and Future Perspectives DOI Open Access
Alicja Balcerak, Monika Dzwonkowska-Zarzycka, Janina Kabatc

et al.

Materials, Journal Year: 2024, Volume and Issue: 17(17), P. 4255 - 4255

Published: Aug. 28, 2024

Today, smart materials are commonly used in various fields of science and technology, such as medicine, electronics, soft robotics, the chemical industry, automotive field, many others. Smart polymeric hold good promise for future due to their endless possibilities. This group advanced can be sensitive changes or presence chemical, physical, biological stimuli, e.g., light, temperature, pH, magnetic/electric pressure, microorganisms, bacteria, viruses, toxic substances, review concerns newest achievements area materials. The recent advances designing stimuli-responsive polymers described this paper.

Language: Английский

Citations

8
Biomedical applications of fluorescent probes for detecting ischemia-reperfusion injury in different organs DOI

Xinying Jing,

Song Han, Yi Yang

et al.

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 534, P. 216607 - 216607

Published: March 14, 2025

Language: Английский

Citations

0
Application of Nanomaterials in the Diagnosis and Treatment of Retinal Diseases DOI

Yufei Yao,

Qiannan Cao,

Huapan Fang

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

Abstract In recent years, nanomaterials have demonstrated broad prospects in the diagnosis and treatment of retinal diseases due to their unique physicochemical properties, such as small‐size effects, high biocompatibility, functional surfaces. Retinal are often accompanied by complex pathological microenvironments, where conventional diagnostic therapeutic approaches face challenges low drug delivery efficiency, risks associated with invasive procedures, difficulties real‐time monitoring. Nanomaterials hold promise addressing these limitations traditional therapies, thereby improving precision efficacy. The applications diagnostics summarized, they enable high‐resolution imaging carrying fluorescent probes or contrast agents act biosensors sensitively detect disease‐related biomarkers, facilitating early dynamic therapeutics, functionalized nanocarriers can precisely deliver drugs, genes, antioxidant molecules target cells, significantly enhancing outcomes while reducing systemic toxicity. Additionally, nanofiber materials possess properties that make them particularly suitable for regeneration tissue engineering. By loading neurotrophic factors into scaffolds, regenerative effects be amplified, promoting repair neurons. Despite immense potential, clinical translation still requires long‐term biosafety, scalable manufacturing processes, optimization targeting efficiency.

Language: Английский

Citations

0
Micro-nano robots for treatment of eye diseases DOI Creative Commons
Haocheng Wang,

Jingxue Sun,

Xiaona Zhang

et al.

Frontiers in Chemistry, Journal Year: 2025, Volume and Issue: 13

Published: April 10, 2025

In recent years, micro-nano robots have found extensive applications in the field of medicine. Among these, demonstrate significant potential for treatment eye diseases. Micro-nano can penetrate tissue barriers to directly target posterior segment precise drug delivery, enabling non-invasive or minimally invasive treatment. This review explores primary fabrication methods and propulsion mechanisms various robots, their treating conditions, offering inspiration guidance advancing use micro-nanorobots ophthalmic therapies.

Language: Английский

Citations

0
Ferritin Fused with MiniSOG for In Vitro Photodynamic Therapy DOI Creative Commons

Narathip Naradun,

Piyasiri Chueakwon,

Anyanee Kamkaew

et al.

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 22, 2025

To avoid off-target effects, targeted cancer therapy offers a feasible alternative to traditional therapies such as chemotherapy and radiotherapy. The human ferritin receptor (transferrin receptor, TfR1) is greatly overexpressed in several types, including liver cancer. Therefore, (HFn) has been used drug encapsulation for therapy. However, the method time-consuming not applicable all conditions. In this study, we effectively designed HFn fused with photosensitizing protein called mini-singlet oxygen generator (miniSOG) create HFn-miniSOG photodynamic (PDT) applications. fusion self-assembled form nanoparticles an average size of 22.4 ± 1.3 nm generated singlet (1O2) when activated by blue-light irradiation ΦΔ = 0.30. demonstrate its PDT capability, phototoxicity was assessed HepG2 HeLa cells varying TfR1 expression levels. viability reduced 63% after light irradiation, compared 34% cells, because exhibit greater levels TfR1. As result, our study provides straightforward approach creating ALL-IN-ONE

Language: Английский

Citations

0
Promoting retinal ganglion cell regeneration with targeted liposome-based delivery of MHY1485 for optic nerve repair DOI

Bingqing Luo,

Tingting Cheng, Ying Xiang

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 383, P. 113778 - 113778

Published: April 25, 2025

Language: Английский

Citations

0
Reprogramming Retinal Microglia Polarization by Efferocytosis-Mimicking Nanoparticles for Ameliorating Diabetic Retinopathy DOI
Zhipeng Li, Wenyu Wang, Liping Zhu

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: May 7, 2025

Diabetic retinopathy (DR), as the most common microvascular complication of diabetes, seriously threatens vision diabetic patients. As resident phagocytes retina, microglia participate in inflammation, neovascularization, and neurodegeneration DR. Herein, apoptotic retinal cell membrane-coated, rapamycin-loaded mesoporous Prussian blue NPs immunomodulators for ameliorating DR by modulating microglial polarization are reported. The apoM@mPB@Ra exhibited favorable stability biocompatibility achieved active targeted delivery due to specific recognition between "eat me" signal expressed on membrane microglia. In an LPS-induced cellular inflammation model, effectively promoted toward anti-inflammatory phenotype (M2) scavenging intracellular reactive oxygen species (ROS) combined with affecting mTOR signaling pathway, leading downregulation pro-inflammatory cytokines IL-6 TNF-α. Meanwhile, owing multienzyme-like activities mPB nanoparticles, obviously alleviated hypoxia, thereby decreasing expression VEGF. Notably, a mouse model DR, intravitreally injected significantly improved severity abnormal vascular network inflammatory microenvironment down-regulating HIF-1α, VEGF, inflammatory-related cytokines. Collectively, these findings demonstrate that provide promising effective approach treatment

Language: Английский

Citations

0