Revolutionizing Alzheimer's treatment: Harnessing human serum albumin for targeted drug delivery and therapy advancements

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 99, P. 102379 - 102379

Published: June 18, 2024

Language: Английский

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Curcumin-loaded polymeric nanomaterials as a novel therapeutic strategy for Alzheimer's disease: A comprehensive review

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 99, P. 102393 - 102393

Published: June 24, 2024

Language: Английский

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Shedding light on Alzheimer's disease: Recent advances in highly selective fluorescent probes

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 522, P. 216221 - 216221

Published: Sept. 16, 2024

Language: Английский

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Curcumin-Loaded Nanoparticles in Neurodegenerative Diseases: Alzheimer’s, Parkinson’s, and Amyotrophic Lateral Sclerosis

Nanotechnology in the life sciences, Journal Year: 2025, Volume and Issue: unknown, P. 225 - 237

Published: Jan. 1, 2025

Language: Английский

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Smart fluorogenic tools: From designing principles to visualization of multistep protein aggregation

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 535, P. 216625 - 216625

Published: March 19, 2025

Language: Английский

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Advancing Nanomaterial-Based Strategies for Alzheimer’s Disease: A Perspective

JACS Au, Journal Year: 2025, Volume and Issue: unknown

Published: March 31, 2025

Alzheimer's disease (AD) is a complex neurodegenerative disorder and the most common cause of dementia. By 2050, number AD cases projected to exceed 131 million, placing significant strain on healthcare systems economies worldwide. The pathogenesis multifactorial, involving hypotheses/mechanisms, such as amyloid-β (Aβ) plaques, tau protein hyperphosphorylation, cholinergic neuron damage, oxidative stress, inflammation. Despite extensive research, complexity these potentially entangled mechanisms has hindered development treatments that can reverse progression. Nanotechnology, leveraging unique physical, electrical, magnetic, optical properties nanomaterials, emerged promising approach for treatment. In this Perspective, we first outlined major current pathogenic hypotheses then reviewed recent advances in nanomaterials addressing hypotheses. We have also discussed challenges translating into clinical applications proposed future directions, particularly multifunctional multitarget enhance their therapeutic efficacy applicability

Language: Английский

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Nano lipid-drug conjugates for the treatment of Alzheimer’s disease

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 237 - 291

Published: Jan. 1, 2025

Language: Английский

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Herbal nanoparticles: a targeted approach for neurodegenerative disorder treatment

Journal of drug targeting, Journal Year: 2024, Volume and Issue: 32(10), P. 1233 - 1246

Published: Aug. 12, 2024

Nanotechnology has significantly impacted human life, particularly in overcoming the limitations associated with neurodegenerative diseases (NDs). Various nanostructures and vehicle systems, such as polymer nanoparticles, carbon nanotubes (CNTs), nanoliposomes, nano-micelles, lipid lactoferrin, polybutylcyanoacrylate, poly lactic-co-glycolic acid, have been shown to enhance drug efficacy, reduce side effects, improve pharmacokinetics. NDs affect millions worldwide are challenging treat due blood-brain barrier (BBB), which hinders delivery central nervous system (CNS). Research suggests that natural ingredients can be formulated into offering a promising approach for ND treatment. This review examines advantages disadvantages of herbal-based nanoformulations, highlighting their potential effectiveness when used alone or combination other medications. Herbal nanoparticles provide benefits over synthetic ones biocompatibility, reduced toxicity, synergistic effects. The study's findings applied develop more efficient improving treatment by enhancing penetration across BBB targeting affected CNS areas precisely.

Language: Английский

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Zwitterionic, Stimuli-Responsive Liposomes for Curcumin Drug Delivery: Enhancing M2 Macrophage Polarization and Reducing Oxidative Stress through Enzyme-Specific and Hyperthermia-Triggered Release

ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 16, 2024

A zwitterionic, stimuli-responsive liposomal system was meticulously designed for the precise and controlled delivery of curcumin, leveraging enzyme-specific hyperthermic stimuli to enhance therapeutic outcomes. This platform is specifically engineered release curcumin in response phospholipase A2, an enzyme that degrades phospholipids, enabling highly targeted site-specific drug release. Mild hyperthermia (40 °C) further enhances membrane permeability activates thermosensitive carriers, optimizing delivery. Curcumin encapsulation facilitated through a combination zwitterionic electrostatic interactions, significantly improving both loading capacity efficiency. design experiments (DoE) approach employed systematically optimize lipid-to-cholesterol ratios formulation conditions. The thoroughly characterized using dynamic light scattering, zeta potential measurements, transmission electron microscopy, ensuring stability structural integrity. Notably, this effectively encapsulates hydrophobic while maintaining particle size bioactivity. In vitro studies revealed robust antioxidant anti-ROS activities, alongside excellent biocompatibility, with no cytotoxicity observed at concentrations up 2000 μg/mL. Furthermore, liposomes enhanced M2 macrophage polarization reduced oxidative stress. advanced offers promising, biocompatible solution

Language: Английский

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A comparative study of PEO-PBO content on the targeting and anti-glioma activity of annonaceous acetogenins-loaded nanomicelles

Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 244, P. 114176 - 114176

Published: Aug. 30, 2024

Language: Английский

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