Cited by Exploring the Biological Efficacy of Zn(II)-Thiosemicarbazone-Ferrocene Complexes: In-Silico and In-Vitro Findings

Comprehensive Analysis of Hydrazone Schiff Bases: Synthesis, Structural Characterization, DFT Studies, Molecular Docking Insights and Bioactivity Assessment DOI

Ashish Kumar Tiwari,

Vaishnu SK,

Mohankumar Narayanan

et al.

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 141905 - 141905

Published: March 1, 2025

Language: Английский

Citations

Ru^III–Morpholine-Derived Thiosemicarbazone-Based Metallodrugs: Lysosome-Targeted Anticancer Agents DOI

Monalisa Mohanty, Sanchita Das,

Pratikshya Das Pattanayak

et al.

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

The idea of coordinating biologically active ligand systems to metal centers exploit their synergistic effects has gained momentum. Therefore, in this report, three RuIII complexes 1–3 morpholine-derived thiosemicarbazone ligands have been prepared and characterized by spectroscopy HRMS along with the structure 2 through a single-crystal X-ray diffraction study. solution stability was tested using conventional techniques such as UV–vis HRMS. Further, anticancer activity HT-29 HeLa cancer cell lines. To gain insight into mechanism action, cytotoxicity, hydrophobicity, interaction DNA HSA were evaluated different methods absorption, fluorescence, circular dichroism studies. Along favorable biomolecule interaction, revealed potent selectivity toward cells, which is prerequisite for generation an drug. According viability results, 1 highest cytotoxicity among all group, against both respectively. Additionally, fluorescence-active ruthenium selectively target lysosomes, live-cell imaging. disrupt lysosome membrane potential generating excessive amount reactive oxygen species, results apoptotic mode death.

Language: Английский

Citations

Targeting Breast and Gynecologic Cancers: The Role of Natural Products with Emphasis on Cinnamon and Its Derivatives—Advances in Nanoscale Therapeutics and Adjuvant Strategies DOI

Mary A. Biggs, Ipsita A. Banerjee

Macromol—A Journal of Macromolecular Research, Journal Year: 2025, Volume and Issue: 5(1), P. 13 - 13

Published: March 18, 2025

Members of the Cinnamomum genus have been utilized for medicinal treatment millennia. In recent years, particular attention has given to bioactive metabolites involved in properties natural products and their extracts. Cinnamon is particularly interesting due presence both terpenoid polyphenol moieties, which extensively studied applications a wide range conditions, from bacterial infection, obesity diabetes cancer cardiovascular pathologies. Here, we reviewed some cinnamon its derivatives cinnamic acid, trans-cinnamaldehyde beta-caryophyllene. addition, advancements application cancer, focusing on gynecological breast cancers, present unique challenges late diagnosis, discussed. Current further enhance delivery through nanoencapsulation nanoparticulate strategies as well development novel conjugates hybrids are also Additionally, use adjuvants with chemotherapeutics that can work synergistically was touched upon. Overall, biotechnological innovations enhanced such may pave path therapeutic fewer side effects higher potency. represents valuable source developing anticancer materials warrant additional research potential interventions or combination treatments.

Language: Английский

Citations

Exploring the Biological Efficacy of Zn(II)-Thiosemicarbazone-Ferrocene Complexes: In-Silico and In-Vitro Findings DOI

Vipin Manakkadan,

Sravan Sangeeth Surendran,

Puthiyavalappil Rasin

et al.

Journal of Inorganic and Organometallic Polymers and Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 2, 2025

Language: Английский

Citations