Synthesis and Characterization of Photocurable Difunctional Monomers for Medical Applications DOI Open Access
Gökhan Demirci, Agata Goszczyńska, Martyna Sokołowska

et al.

Polymers, Journal Year: 2024, Volume and Issue: 16(24), P. 3584 - 3584

Published: Dec. 21, 2024

Photocurable materials offer a rapid transition from liquid to solid state, and have recently received great interest in the medical field. However, while dental resins are very popular, only few been developed for soft tissue repair. This study aims synthesize difunctional methacrylate monomer using dibutyltin dilaurate which is suitable photocuring of materials. These were compared with PhotoBioCure® (Szczecin, Poland) material similar molecular weight, Mn ~7000 g/mol on average. Infrared spectroscopy was used monitor two-step synthesis catalyzed dilaurate, spectroscopic chromatographic methods determine chemical structure weight monomers. Photopolymerization kinetics under varying light intensities explored nitrogen atmosphere representative The mechanical testing resulting elastomeric films confirmed tensile strength modulus values consistent parameters range 3–4 MPa. 3D printability macromonomers also assessed. Additionally, cytotoxicity assessments cultured cells showed high cell viability (97%) all new Overall, we demonstrate that monomers converted flexible solids during photopolymerization show potential biomedical applications.

Language: Английский

Injectable Fluorescent Bottlebrush Polymers for Interventional Procedures and Biomedical Imaging DOI
Yichun Yuan,

Sophia Beilharz,

Heather R. Everson

et al.

Biomacromolecules, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 24, 2025

Injectable biomaterials play a vital role in modern medicine, offering tailored functionalities for diverse therapeutic and diagnostic applications. In ophthalmology, instance, viscoelastic materials are crucial procedures such as cataract surgery but often leave residues, increasing postoperative risks. This study introduces injectable fluorescent viscoelastics (FluoVs) synthesized via one-step controlled radical copolymerization of oligo(ethylene glycol) acrylate fluorescein acrylate. These bottlebrush-shaped polymers exhibit enhanced fluorescence intensity improved traceability facile removal postsurgery. To prevent aggregation, charged terpolymers were synthesized, ensuring intra- intermolecular electrostatic repulsion. Dynamic light scattering energy-conserved dissipative particle dynamics simulations revealed how the content monomer sequence affect hydrodynamic size these copolymers. Biocompatibility assessments showed that FluoVs maintained cell viability comparable to commercial hydroxypropyl methylcellulose nonfluorescent poly(oligo(ethylene acrylate) controls. The combine high intensity, low viscosity, excellent biocompatibility, intraoperative significant advancements ocular bioimaging

Language: Английский

Citations

0
Hierarchical chitin and chitosan-derived heterostructural nanocomposites: From interdisciplinary applications to a sustainable vision DOI
Le Gia Trung,

Jin Seog Gwag,

Ha Huu

et al.

Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: unknown, P. 123702 - 123702

Published: May 1, 2025

Language: Английский

Citations

0
Synthesis and Characterization of Photocurable Difunctional Monomers for Medical Applications DOI Open Access
Gökhan Demirci, Agata Goszczyńska, Martyna Sokołowska

et al.

Polymers, Journal Year: 2024, Volume and Issue: 16(24), P. 3584 - 3584

Published: Dec. 21, 2024

Photocurable materials offer a rapid transition from liquid to solid state, and have recently received great interest in the medical field. However, while dental resins are very popular, only few been developed for soft tissue repair. This study aims synthesize difunctional methacrylate monomer using dibutyltin dilaurate which is suitable photocuring of materials. These were compared with PhotoBioCure® (Szczecin, Poland) material similar molecular weight, Mn ~7000 g/mol on average. Infrared spectroscopy was used monitor two-step synthesis catalyzed dilaurate, spectroscopic chromatographic methods determine chemical structure weight monomers. Photopolymerization kinetics under varying light intensities explored nitrogen atmosphere representative The mechanical testing resulting elastomeric films confirmed tensile strength modulus values consistent parameters range 3–4 MPa. 3D printability macromonomers also assessed. Additionally, cytotoxicity assessments cultured cells showed high cell viability (97%) all new Overall, we demonstrate that monomers converted flexible solids during photopolymerization show potential biomedical applications.

Language: Английский

Citations

0