Photosensitizable ZIF-8 BioMOF for Stimuli-Responsive Antimicrobial Phototherapy DOI
Angana De, Yeddula Nikhileshwar Reddy, Shatabdi Paul

et al.

Molecular Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 21, 2025

Resistant pathogens are increasingly posing a heightened risk to healthcare systems, leading growing concern due the lack of effective antimicrobial treatments. This has prompted adoption photodynamic therapy (aPDT), which eradicates microorganisms by generating reactive oxygen species (ROS) through utilization photosensitizer, photons, and molecular oxygen. However, challenge arises from inherent characteristics photosensitizers, including photobleaching, aggregation, self-quenching. Consequently, strategy been devised adsorb or bind photosensitizers diverse carriers facilitate their delivery. Notably, metal–organic frameworks (MOFs) have emerged as promising means transporting even though achieving uniform particle sizes room-temperature synthesis remains complex task. In this work, we tackled issue heterogeneous size distribution in MOFs, 150 ± 50 nm. Subsequently, harnessed Zeolite Imidazolate Framework 8 (ZIF-8), an excellent subclass biocompatible MOF, effectively load two distinct categories namely, Rose Bengal (RB) porphyrin, using simple, straightforward, single-step process. Our findings indicate that prepared RB@ZIF-8 generates more substantial amount singlet when subjected photoirradiation (using green light-emitting diode (LED)) at low concentrations, comparison with porphyrin@ZIF-8, demonstrated vitro experiments. Additionally, investigated pH-responsive behavior ascertain its implications under biological conditions. Correspondingly, exhibited favorable IC50 value against Escherichia coli compared bare ZIF-8 alone, other photosensitizer-loaded complexes. underscores potential BioMOF for combatting multidrug-resistant bacteria across spectrum infection scenarios, complemented responsiveness stimuli.

Language: Английский

Photosensitizable ZIF-8 BioMOF for Stimuli-Responsive Antimicrobial Phototherapy DOI
Angana De, Yeddula Nikhileshwar Reddy, Shatabdi Paul

et al.

Molecular Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 21, 2025

Resistant pathogens are increasingly posing a heightened risk to healthcare systems, leading growing concern due the lack of effective antimicrobial treatments. This has prompted adoption photodynamic therapy (aPDT), which eradicates microorganisms by generating reactive oxygen species (ROS) through utilization photosensitizer, photons, and molecular oxygen. However, challenge arises from inherent characteristics photosensitizers, including photobleaching, aggregation, self-quenching. Consequently, strategy been devised adsorb or bind photosensitizers diverse carriers facilitate their delivery. Notably, metal–organic frameworks (MOFs) have emerged as promising means transporting even though achieving uniform particle sizes room-temperature synthesis remains complex task. In this work, we tackled issue heterogeneous size distribution in MOFs, 150 ± 50 nm. Subsequently, harnessed Zeolite Imidazolate Framework 8 (ZIF-8), an excellent subclass biocompatible MOF, effectively load two distinct categories namely, Rose Bengal (RB) porphyrin, using simple, straightforward, single-step process. Our findings indicate that prepared RB@ZIF-8 generates more substantial amount singlet when subjected photoirradiation (using green light-emitting diode (LED)) at low concentrations, comparison with porphyrin@ZIF-8, demonstrated vitro experiments. Additionally, investigated pH-responsive behavior ascertain its implications under biological conditions. Correspondingly, exhibited favorable IC50 value against Escherichia coli compared bare ZIF-8 alone, other photosensitizer-loaded complexes. underscores potential BioMOF for combatting multidrug-resistant bacteria across spectrum infection scenarios, complemented responsiveness stimuli.

Language: Английский

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