Nanomaterial-Based Strategies to Combat Antibiotic Resistance: Mechanisms and Applications DOI Creative Commons
Nargish Parvin, Sang Woo Joo, Tapas Kumar Mandal

et al.

Antibiotics, Journal Year: 2025, Volume and Issue: 14(2), P. 207 - 207

Published: Feb. 18, 2025

The rapid rise of antibiotic resistance has become a global health crisis, necessitating the development innovative strategies to combat multidrug-resistant (MDR) pathogens. Nanomaterials have emerged as promising tools in this fight, offering unique physicochemical properties that enhance efficacy, overcome mechanisms, and provide alternative therapeutic approaches. This review explores diverse nanomaterial-based used resistance, focusing on their mechanisms action practical applications. such metal nanoparticles, carbon-based nanomaterials, polymeric nanostructures exhibit antibacterial through various pathways, including generation reactive oxygen species (ROS), disruption bacterial membranes, enhancement delivery. Additionally, ability nanomaterials bypass traditional biofilm formation efflux pumps, been demonstrated numerous studies. also discusses synergistic effects observed when are combined with conventional antibiotics, leading increased susceptibility reduced required dosages. By highlighting recent advancements clinical applications nanomaterial-antibiotic combinations, paper provides comprehensive overview how reshaping future therapies. Future research directions challenges, toxicity scalability, addressed guide safer, more effective treatments.

Language: Английский

Nanomaterial-Based Strategies to Combat Antibiotic Resistance: Mechanisms and Applications DOI Creative Commons
Nargish Parvin, Sang Woo Joo, Tapas Kumar Mandal

et al.

Antibiotics, Journal Year: 2025, Volume and Issue: 14(2), P. 207 - 207

Published: Feb. 18, 2025

The rapid rise of antibiotic resistance has become a global health crisis, necessitating the development innovative strategies to combat multidrug-resistant (MDR) pathogens. Nanomaterials have emerged as promising tools in this fight, offering unique physicochemical properties that enhance efficacy, overcome mechanisms, and provide alternative therapeutic approaches. This review explores diverse nanomaterial-based used resistance, focusing on their mechanisms action practical applications. such metal nanoparticles, carbon-based nanomaterials, polymeric nanostructures exhibit antibacterial through various pathways, including generation reactive oxygen species (ROS), disruption bacterial membranes, enhancement delivery. Additionally, ability nanomaterials bypass traditional biofilm formation efflux pumps, been demonstrated numerous studies. also discusses synergistic effects observed when are combined with conventional antibiotics, leading increased susceptibility reduced required dosages. By highlighting recent advancements clinical applications nanomaterial-antibiotic combinations, paper provides comprehensive overview how reshaping future therapies. Future research directions challenges, toxicity scalability, addressed guide safer, more effective treatments.

Language: Английский

Citations

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