Tissue-Informed Biomaterial Innovations Advance Pulmonary Regenerative Engineering DOI

Anton D. Kary,

Haley Noelle,

Chelsea M. Magin

et al.

ACS Macro Letters, Journal Year: 2025, Volume and Issue: unknown, P. 434 - 447

Published: March 18, 2025

Irreversible progressive pulmonary diseases drastically reduce the patient quality of life, while transplantation remains only definitive cure. Research into lung regeneration pathways holds significant potential to expand and promote discovery new treatment options. Polymeric biomaterials designed replicate key tissue characteristics (i.e., biochemical composition mechanical cues) show promise for creating environments in which study chronic initiate regeneration. In this Viewpoint, we explore how naturally derived materials can be employed alone or combined with engineered polymer systems create advanced culture platforms. Pulmonary models have historically leveraged natural materials, including basement membrane extracts a decellularized extracellular matrix, as platforms studies. Here, provide an overview progression regenerative engineering, exploring innovations growing field tissue-informed advance research by bridging gap between biological relevance precision.

Language: Английский

Tissue-Informed Biomaterial Innovations Advance Pulmonary Regenerative Engineering DOI

Anton D. Kary,

Haley Noelle,

Chelsea M. Magin

et al.

ACS Macro Letters, Journal Year: 2025, Volume and Issue: unknown, P. 434 - 447

Published: March 18, 2025

Irreversible progressive pulmonary diseases drastically reduce the patient quality of life, while transplantation remains only definitive cure. Research into lung regeneration pathways holds significant potential to expand and promote discovery new treatment options. Polymeric biomaterials designed replicate key tissue characteristics (i.e., biochemical composition mechanical cues) show promise for creating environments in which study chronic initiate regeneration. In this Viewpoint, we explore how naturally derived materials can be employed alone or combined with engineered polymer systems create advanced culture platforms. Pulmonary models have historically leveraged natural materials, including basement membrane extracts a decellularized extracellular matrix, as platforms studies. Here, provide an overview progression regenerative engineering, exploring innovations growing field tissue-informed advance research by bridging gap between biological relevance precision.

Language: Английский

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