Cited by Preparation of mitochondria-targeted camptothecin derivatives for the imaging and antiproliferation of colorectal cancer

YOPRO-1: A Cyanine-Based Molecular Rotor Probe for Amyloid Fibril Detection DOI

Sailee D. Shahane,

Niyati H. Mudliar,

Bhavya R. Chawda

et al.

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

The widespread occurrence of amyloidosis in many neurodegenerative diseases, including Alzheimer's, highlights the urgent need for early detection methods. Traditional approaches often fall short sensitivity, specificity, and ability to operate within complex biological matrices. Fluorescence spectroscopy, which leverages unique properties extrinsic fluorescence sensors, has emerged as a promising avenue amyloid detection. Thioflavin-T (ThT), while extensively utilized, faces several disadvantages such poor blood-brain barrier penetration, emission wavelength, lack sensitivity oligomeric protein aggregates. These limitations necessitate development improved probes with enhanced better understanding diseases. In this context, YOPRO-1, cyanine-based molecular rotor probe, been identified potent fibril sensor characterized by its turn-on response specificity fibrils over native forms. Utilizing variety spectroscopic techniques, steady-state emission, ground-state absorption, time-resolved fluorescence, docking, we demonstrate superior selectivity YOPRO-1 fibrils. probe exhibits remarkable 245-fold increase intensity upon binding insulin fibrils, is common model. This capability facilitates application matrices, high-percentage human serum, rarely demonstrated previous sensing probes. Furthermore, commercial availability avoids challenges associated synthesis specific probes, thereby marking significant advancement methodologies. Our findings highlight potential versatile effective tool diagnosis amyloid-related offering foundation future therapeutic diagnostic applications.

Language: Английский

Citations

Hemicyanine-based fluorescent probes: Advancements in biomedical sensing and activity-based detection DOI

Saleh Muhammad,

Haroon Ahmad,

Yuqian Yan

et al.

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 534, P. 216602 - 216602

Published: March 14, 2025

Language: Английский

Citations

Preparation of mitochondria-targeted camptothecin derivatives for the imaging and antiproliferation of colorectal cancer DOI

Chenmeng Xu,

Rui Wang, Jia Li

et al.

Bioorganic & Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 118267 - 118267

Published: June 1, 2025

Language: Английский

Citations